alexa Metabolic Fingerprinting In Patients With Acute Pulmonary Embolism
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

World Heart Congress
May 22- 24, 2017 Osaka, Japan

Izabela Kiluk, P Samczuk, R Bujak, A Kretowski, M Ciborowski and B Sobkowicz
Medical University of Bialystok, Poland
Medical University of Gdansk, Poland
Posters & Accepted Abstracts: J Clin Exp Cardiolog
DOI: 10.4172/2155-9880-C1-069
Abstract
Introduction: Pulmonary embolism (PE) is a major cause of mortality, morbidity, and hospitalization in Europe. In 30-40% cases of the PE, the cause (idiopathic or unprovoked PE) cannot be determined. Nowadays, metabolomics becomes important part of clinical studies. It can help to understand the disease process and propose diagnostic and prognostic biomarkers. Until, now, there was no study using untargeted metabolomics in population of acute PE patients. Purpose: The purpose of the study is to apply metabolomics to evaluate prognosis factors and identify novel diagnostic and prognostic markers for PE, what can also bring new insight into disease pathophysiology. Methods: Prospective analysis of plasma samples collected from 42 patients hospitalized in Cardiology Department (proven acute PE, treated with low molecular weight heparin (LMWH)) and 13 healthy controls treated with adequate dose of LMWH was performed. Samples were fingerprinted with LC-QTOF-MS. Differences between patients’ subgroups (all PE patients, control after drug (CAD), subgroups of idiopathic PE patients with and without deep vein thrombosis (DVT)) and controls were evaluated. Depending on data distribution t-test or Mann-Whitney test were used. Results: Performed metabolomics analysis resulted in detection of more than 200 significantly altered metabolites. Multivariate statistics confirmed clear separation between the examined groups. Venn diagrams allow selecting common and differentiating compounds for particular comparison (Figure1). Significant changes were observed in level of cholesterol derivatives, acylcarnitines, phospholipids, fatty acid (like arachidonic acid) and their amides. Conclusions: Metabolic fingerprinting could be helpful to improve diagnosis and to understand pathophysiological mechanisms related to acute PE. The metabolites significantly different in acute PE patients were associated with hypoxia, lipid-related energy imbalance, alterations in mitochondrial function and signal transduction pathways. Moreover, some of the detected compounds were linked with cardiovascular diseases before.
Biography

Izabela Kiluk is a very promising Young Doctor, who started training in Cardiology in 01.01.2013 and PhD studies in 01.10.2013. Currently, she works as Resident Physician in the Department of Cardiology, Medical University of Bialystok Clinical Hospital. Since 4th year of the studies at the Medical University of Bialystok, she has been particularly interested in Cardiology and exhibited considerable part in the activities of Student’s Scientific Group of Department of Cardiology. During this time, she has proven to be a hardworking and dedicated Student, Scientist and now Physician, who would benefit from participation in such world-renowned event. She is the author of several publications concerning acute pulmonary embolism.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords