alexa Method Of Calculation The Actual Values Of The Parameters Of Drug Elimination
ISSN: 2167-0870

Journal of Clinical Trials
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th Global Pharmacovigilance & Drug Safety Summit
JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA

Ilin A I and Asmanova N
Scientific Center for Anti-Infection Drugs, Kazakhstan
Posters & Accepted Abstracts: J Clin Trial
DOI: 10.4172/2167-0870-C1-017
Abstract
Statement of the Problem: The half-life t1/2 or t1/2(β) is an indispensable characteristic to any drug, because it is one of the pharmacokinetic (PK) parameters required for the calculation of its dosage regimen. But, now in use the methods of calculation t1/2, which are valid only for the so-called monoexponential curve. They are also subject to the rule t1/2 / MRT=ln 2, where MRT - mean residence time. In reality, there are many cases of deviation from it: ln 2 t1.2/MRT>1. According to the results of our investigation [1], they are logically related with the number of compartments in a PK parameters on base of curve C10 (t) / C0 =f (t) :a -model and mode of the drug administration, thus the relation (C10 / C0 ) fix→tcalc , b - t fix→(C10 / C0 )calc t1/ 2(β) / MRT can be recommended as an additional its characteristic. The aim of this study is to devise a method for determining an actual values t1/2 and MRT. Methodology & Theoretical Orientation: By analysis of mathematical tool, numerical simulation and experimental data from literature it was shown, that to the determination of the actual values t1/2 and MRT instead PK curve of blood one must use the curve of the drug elimination from it. The problem of non-uniqueness of solutions [2-5] can be avoided by using the value C10 (t) / C0 or its equivalent - AUC0-t / AUC0-α. Findings: Based on elimination curves it is possible to calculate not only an actual values t1/2 and MRT, but also others parameters of drug elimination: the time- tcalc , required for the elimination from the blood of a given fraction of administered dose of drug - (C10 / C0 ) fix , or, conversely, to find its value- (C10 / C0 )calc at any point in time - t fix. Conclusion & Significance: The proposed method make possible properly evaluate the parameters of drug elimination, optimize the dosage regimen and, consequently, will enhance their effectiveness.
Biography

Ilin Aleksander I. - His research is associated with the development and creation of new drugs based on iodine-organic compounds. The main advantages of these drugs are a wide spectrum of action and a practical lack of resistance to them in microorganisms.

The purpose of research, conducted by Asmanova Nazira in the last years - theory and practice of handling experimental data of pharmacokinetic studies of drugs. This is due to the fact that some properties PK models and methods of estimation the values of PK parameters are still controversial or even incorrect, which can lead to undesirable consequences.

Email: [email protected] [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords