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|Ilin A I and Asmanova N|
|Scientific Center for Anti-Infection Drugs, Kazakhstan|
|Posters & Accepted Abstracts: J Clin Trial|
|Statement of the Problem: The half-life t1/2 or t1/2(β) is an indispensable characteristic to any drug, because it is one of the pharmacokinetic (PK) parameters required for the calculation of its dosage regimen. But, now in use the methods of calculation t1/2, which are valid only for the so-called monoexponential curve. They are also subject to the rule t1/2 / MRT=ln 2, where MRT - mean residence time. In reality, there are many cases of deviation from it: ln 2 t1.2/MRT>1. According to the results of our investigation , they are logically related with the number of compartments in a PK parameters on base of curve C10 (t) / C0 =f (t) :a -model and mode of the drug administration, thus the relation (C10 / C0 ) fix→tcalc , b - t fix→(C10 / C0 )calc t1/ 2(β) / MRT can be recommended as an additional its characteristic. The aim of this study is to devise a method for determining an actual values t1/2 and MRT. Methodology & Theoretical Orientation: By analysis of mathematical tool, numerical simulation and experimental data from literature it was shown, that to the determination of the actual values t1/2 and MRT instead PK curve of blood one must use the curve of the drug elimination from it. The problem of non-uniqueness of solutions [2-5] can be avoided by using the value C10 (t) / C0 or its equivalent - AUC0-t / AUC0-α. Findings: Based on elimination curves it is possible to calculate not only an actual values t1/2 and MRT, but also others parameters of drug elimination: the time- tcalc , required for the elimination from the blood of a given fraction of administered dose of drug - (C10 / C0 ) fix , or, conversely, to find its value- (C10 / C0 )calc at any point in time - t fix. Conclusion & Significance: The proposed method make possible properly evaluate the parameters of drug elimination, optimize the dosage regimen and, consequently, will enhance their effectiveness.|
Ilin Aleksander I. - His research is associated with the development and creation of new drugs based on iodine-organic compounds. The main advantages of these drugs are a wide spectrum of action and a practical lack of resistance to them in microorganisms.
The purpose of research, conducted by Asmanova Nazira in the last years - theory and practice of handling experimental data of pharmacokinetic studies of drugs. This is due to the fact that some properties PK models and methods of estimation the values of PK parameters are still controversial or even incorrect, which can lead to undesirable consequences.
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