MicroRNA Expression In Advanced Breast Cancer | 65562
Journal of Cancer Science & Therapy
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Statement of the Problem: Although early stage breast cancer has a high cure rate with current treatment modalities, advanced
breast cancer remains a life threatening disease. There is an urgent need for new therapeutic targets. Inflammatory breast
cancer, comprising 1-5% of newly diagnosed breast cancer in the United States, is the most aggressive form of breast cancer,
characterized by clinical hallmarks of diffuse erythema and edema and rapid progression from the onset. Recent advances
have implicated the role of microRNAs as oncogenes or tumor suppressor genes in tumorigenesis, metastasis and response to
treatment in various cancer types including breast cancer. The aim of our ongoing study is to identify microRNA molecules
that are regulated in advanced breast cancer, including inflammatory breast cancer.
Methodology & Theoretical Orientation: MicroRNA expression profiles of human advanced breast cancer including
inflammatory breast cancer were compared to normal breast tissue using a previously validated microRNA microarray assay.
The results were subsequently validated by quantitative reverse transcription PCR and in situ hybridization.
Findings: There was distinct segregation between tumor and normal breast tissue in microRNA expression profiles. In contrast,
between inflammatory breast cancer and non-inflammatory breast cancer, distinct clustering was not readily identified in
the microarray analysis. However, several microRNAs were differentially expressed in inflammatory breast cancer. We have
validated some molecules by quantitative PCR and in situ hybridization. For example, miR-205 expression was decreased not
only in tumor compared with normal breast tissue, but also in inflammatory breast cancer compared with non-inflammatory
breast cancer. Lower expression of miR-205 was associated with worse distant metastasis-free survival and overall survival in
Conclusion & Significance: MicroRNAs may serve as therapeutic targets in advanced breast cancer.
Lei Huo is a practicing Breast Pathologist in The University of Texas MD Anderson Cancer Center. She is actively involved in clinical and translational research in the field of Breast Cancer. Her research interests include molecular and immunohistochemical markers in tumorigenesis, diagnosis and treatment of breast cancer, among others.