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MicroRNA In Multiple Sclerosis: New Biomarkers And Potential Targets For Treatment | 19477
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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3rd International Conference and Exhibition on Neurology & Therapeutics

Konstantin E Balashov and Latt Latt Aung
Accepted Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.S1.023
Abstract
Agrowing body of scientific evidence indicates that microRNAs (miRNA) are abnormally expressed in patients with multiple sclerosis (MS). B cells are implicated in the pathogenesis of MS. The role of miRNA in MS is not well understood. It was studied if miRNAs regulate pro-inflammatory capabilities of B cells in MS. B cells and monocytes were separated from untreated patients with MS and age- and gender-matched control healthy subjects (CHS). Expression of 904 miRNAs was tested by microarrays followed by validation with real-time qPCR. Expression of miR-320 was significantly decreased in B cells of patients compared to CHS, p=0.014, but not in monocytes. Protein expression of Matrix metallopeptidase 9 (MMP-9), the protein implicated in disruption of blood-brain barrier and is specifically targeted by miR-320, was significantly increased in B cells of patients. To test whether endogenous miRNA-320 inhibits MMP-9 secretion and TFRC expression, B cells from CHS were transfected with specific miR-320 inhibitor which led to increased MMP-9 expression and secretion. In summary, miR-320 expression is selectively decreased in B cells of patients with MS. This is associated with increased expression of miR- 320-specific target, MMP-9, which promotes blood-brain barrier disruption. The author will discuss promise and obstacles in using microRNAs as biomarkers of disease activity and potential targets for MS treatment.
Biography
Konstantin E Balashov, MD, PhD, FAAN, is an Associate Professor of Neurology at Rutgers-Robert Wood Johnson Medical School. He is trained in clinical neurology and immunology and actively conducts clinical studies in multiple sclerosis. He has published more than 40 papers in peer-reviewed journals.
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