alexa MicroRNA-210 Is Involved In Early Cognitive Impairment Induced By Chronic Cerebral Hypoperfusion In Rats Through Regulation Of Snap25
ISSN: 2327-5162

Alternative & Integrative Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

7th International Conference on Ayurveda, Homeopathy and Chinese Medicine
May 18-19, 2017 Munich, Germany

Zhenxing Ren
Guangzhou University, China
ScientificTracks Abstracts: Altern Integr Med
DOI: 10.4172/2327-5162-C1-023
Abstract
Vascular dementia (VD) is the most common form of dementia in the elderly. However, little is understood about the roles of microRNAs (miRNAs) in cognitive impairment in early VD. Here, rats with 4 weeks chronic ischemia showed early impaired acquisition of spatial learning in Morris water maze test. We further investigated the roles of miRNAs in cognitive impairment. The miRNA expression microarrays on RNA extracted from the hippocampus of rats with 4 weeks chronic ischemia and control rats were used. Real-time reverse transcription PCR was conducted to verify the candidate miRNAs discovered by microarray analysis. The data showed that miR-210 was increased significantly in the hippocampus of rats with 4 weeks chronic ischemia, which were concomitant with that rats displayed a significant synaptic loss and cognitive deficits. Bioinformatic analysis predicted that snap25 mRNA is targeted by miR-210. Overexpression of miR-210 lowers the levels of snap25 and synaptic proteins expression in PC12 cells damage induced by serum-free. In contrast, suppression of miR-210 by miR-210 inhibitor significantly results in higher levels of snap25 and synaptic proteins expression. Taken together, miR-210 is involved in cognitive impairment in rats with chronic ischemiainduced vascular dementia through regulation of snap25.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords