alexa Mir193a Expression Pattern In Lymph, Spleen And Brain Samples And Cell Cultures Of Experimental Autoimmune Encephalomyelitis Induced Mice
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Neuroimmunology & Therapeutics
December 01-02, 2016 Atlanta, USA

Saba Gharibi, Mohammad Bagher Mahmoudi, Bahram Moghimi, Mohammad Taher Tahoori, Ensieh Shahvazian and Ehsan Farashahi Yazd
Shahid Sadoughi University of Medical Sciences and Health Services, Iran
ROJETechnologies, Iran
Posters & Accepted Abstracts: J Neurol Disord
DOI: 10.4172/2329-6895.C1.015
Abstract
Tau is naturally a neuron-specific soluble protein that promotes microtubule assembly and stabilization. When pathologically modified, tau dissociates from microtubules and becomes insoluble aggregates called neurofibrillary tangles (NFTs). The NFTs formation is one of the main significant pathological signatures in Alzheimer’s disease (AD) and multiple neurodegenerative disorders classified as tauopathies. NFTs are accumulated in axons and dendrites, thereby causing degeneration of tangle-bearing neurons. In addition, tau oligomers propagate in neurons and acting as a seed for native tau aggregation. Accordingly, great efforts have been made to investigate the mechanism of tau aggregation and to identify the pathogenic tau species. Diverse intracellular modifications make soluble tau to be a susceptible substrate for the soluble tau oligomers and insoluble filamentous aggregates. Due to the implications of tau pathology in many neuro-degenerative disorders, preventing the pathological tau aggregation become an important therapeutic strategy to halt the disease. However, progress has been slow due to the lack of understating tau aggregation mechanism. Tau aggregation is a multi-step process regulated by complicated cellular pathways. In tau pathology, diverse tau modifications including phosphorylation, oxidation, acetylation and truncation promote tau aggregation in a defected neuron. At the same time, the neuron activates cellular defense mechanisms such as glycosylation. We are currently focusing on diverse tau modifications associated with tau aggregation, strategy of tau aggregation inhibition, small molecule for tau imaging, and cell-based model that could monitor and quantify tau aggregation process in living cells.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version