alexa Mitochondria In Kidney Pathologies (ischemic Kidney, Rhabdomyolysis, Pyelonephritis)
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

10th European Nephrology Conference
October 24-26, 2016 Rome, Italy

Dmitry Zorov
Moscow State University, Russia
Keynote: J Nephrol Ther
DOI: 10.4172/2161-0959.C1.032
Abstract
Mitochondria play a key role in the pathogenesis of various diseases, including renal pathologies, especially those that occur with the participation of oxidative stress. Among these are kidney ischemia, rhabdomyolysis and pyelonephritis. Mitochondria are not only a cause but also a target of oxidative stress as a result of insufficient tissue supply of oxygen and nutrients, and a hyperinflammatory response associated with these pathologies. As a result, the mitochondria respond by enhanced generation of reactive oxygen species (ROS) (ROS-induced ROS release) and by activation of production of proinflammatory cytokines, whose redundancy is fatal. In the case of pyelonephritis, pathogenic factors are not only bacterial antigens that activate innate immune response through activation of toll-like receptors of leukocytes and epithelial cells, but also proinflammatory cytokines and ROS. The strategy of treatment for such pathologies is that primary targets of pharmacological action must be the mitochondrion with the final goal to retain normal mitochondrial structure and function as a mandatory requirement which can provide renal protection. In the case of ischemic renal damage, one of the most effective approaches to protect the organ is ischemic preconditioning. All protective signaling pathways converge on mitochondria, namely on GSK-3β, which gives the possibility of targeted influence on the end effector of protective signaling. Pharmacological preconditioning is just an imitation of ischemic preconditioning. In most types of protective and destructive signaling pathways, the key role is played by ROS, the maintenance of which at the optimum level is a primary goal for normal functioning of renal tissue.
Biography

D B Zorov has completed his PhD in 1974 from Lomonosov Moscow State University and his Doctor of Science in 1988 from Moscow University. He is the Chief of the Department of Functional Biochemistry of Biopolymers and the Chief of the Laboratory of Mitochondrial Structure and Functions in A N Belozersky Institute at Moscow State University. He has published more than 150 papers in high rank journals and has been serving as an Editorial Board Member of Heart, Lung and Circulation. He is a Member of European Academy (Academia Europea).

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords