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The present topic under discussion owes its credibility to the ?WARBURGS EFFECT? and the subsequent findings that state
the behaviour of the tumor cells towards their process of energy generation when compared with normal cells which usually
rely upon the energy releasing pathways viz. GLYCOLYSIS and OXIDATIVE PHOSPHORYLATION. The tumor cells unlike the
normal cells up regulate the process of glycolysis even under aerobic conditions to meet their energy demands and there is ample
room for an insight into the possible mechanisms responsible for the up regulation of the glycolytic pathway and compromise
of the mitochondrial functions. The past decade has also witnessed the role of Mitochondria in APOPTOSIS( Programmed
Cell Death) by the intrinsic and extrinsic mechanisms involving the CASPASES. This topic discusses the imbalance between
the pro apoptotic and anti-apoptotic proteins viz. Bcl-2 and Bax in tumors and the role of p53, HIF-1(HYPOXIA INDUCIBLE
FACTOR-1 that plays a role in up regulating the enzymes pyruvate dehydrogenase and lactate dehydrogenase in tumor cells )
in the shift of energy releasing pathway from oxidative phosphorylation to glycolysis and how the shift could affect the outer
mitochondrial membrane, that plays a crucial role in triggering apoptosis. Owing to the finding in the past years, thorough
insight into the role of Mitochondria in cancers could aid in serving as a source for promising targets that can shift the energy
pathway from glycolysis and stimulate the silent or suppressed apoptotic pathways.
T. Jayaprakash has completed his B.pharm in Sri Siddhartha Pharmacy College, Nuzvid affiliated to Acharya Nagarjuna University, Guntur. He has
qualified in GPAT-2011. Now he is doing his M.paharm with pharmacology specialization in Jawaharlal Nehru technological University, Kakinada. His
areas of interest are Regulatory affairs, Research & Development, Pre-clinical studies.
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