alexa Modulation Of Immunization Via Cholinergic Nervous System Using HI-6
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Congress on Bacteriology & Infectious Diseases
November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Miroslav Pohanka
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.002
Abstract
HI-6 is a compound known in some sources as asoxime. It is used as an antidote to nerve agents. When HI-6 is administered to the poisoned one, it causes return of acetylcholinesterase (AChE) activity. In recent works, we proved that HI-6 acts as an antagonist to acetylcholine receptors (AChR) including the nicotinic receptor, alpha 7 nAChR which is involved in regulating the immune response through macrophages. The here presented experiment reports the efficacy of HI-6 to regulate the immune response. Laboratory BALB/c mice received HI-6 and/or keyhole limpet hemocyanin (KLH) as an antigen. Controls received saline or a combination of Freund?s complete adjuvant and KLH. Antibody production was investigated after either 21 or 65 days when either single or repeated dose of antigen was applied. We confirmed that HI-6 significantly improved vaccination efficacy when KLH was given in a dose of 1 mg/kg. The effect was dose dependent: repeated HI-6 produced no on further improvement of the vaccination. A combination of HI-6 and KLH produced a vaccination of almost the same efficacy as that for Freund?s complete adjuvant. The findings point at the suitability of HI-6 for improving vaccination efficacy at the level of immunity regulation by the nervous system. Acknowledgments: The Ministry of Education, Youth and Sports of the Czech Republic is gratefully acknowledged for project LH11023. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Biography
Miroslav Pohanka, RNDr., Ph.D., has completed his Ph.D. in biochemistry at Masaryk University, Czech Republic. Currently, he is an Associate Professor and Head of a research group in Faculty of Military Health Sciences, University of Defence, Czech Republic. He published more than 150 papers in journals with IF and he serves as an editorial board member of Journal of Biosensors and Bioelectronics, Journal of Bioterrorism and Biodefence, Journal of Biosafety, Obesity and Weight Loss Therapy. He leads national and international projects on analytical devices construction, immunomodulation and others. His major research activity is given to construction of analytical tools for diagnosis/detection of pathogens, immunomodulation research and research on drugs regulating cholinergic nervous system.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

n[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords