Reach Us +44-1522-440391
Molecular, Cellular And In Vivo Functions Of Integrin-associated CD151 In The Kidney | 4327
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Molecular, cellular and in vivo functions of integrin-associated CD151 in the kidney

International Conference and Exhibition on Nephrology & Therapeutics

Xiuwei Yang

ScientificTracks Abstracts: J Nephrol Therapeut

DOI: 10.4172/2161-0959.S1.004

T he objective of present investigation is to search lead molecules from natural products as a part of drug discovery campaigns in the management of kidney stones. We employed modern technologies in finding promiscuous molecules from a treasure of Indian Ayurvedic system of medicine. Inspired by a pending appeal from therapeutic area of kidney stone to add effective drug in its armamentarium, we explored Gokshuradi Yog (GY) formulation, due to its continuous use in kidney stone management by Ayurvedic practitioners. Bioassay guided isolation of leads from individual plant extracts of GY formulation was done by employing GOx from spinach. These bioassay guided leads isolated were characterized and its structures elucidated by analytical techniques. In silico molecular modeling of those molecules was done at active site of GOx and it has revealed potential binding with key amino acid residues conserved within the active site. Antiurolithic activity of the isolated leads was confirmed in an in vivo model of ethylene glycol induced urolithiasis in experimental rats.