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Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain
tumor in human and is classifi ed by the WHO in the group of diff usely infi ltrative
astrocytomas, representing the most malignant subtype of them. Th e aberrant genetic events
and signaling pathways have been clearly demonstrated. Th ey are cellular, highly anaplastic, and
morphologically highly heterogeneous tumors. Understanding the genetic alterations, specifi c
molecular biomarkers and proliferative pathways might promote therapeutic development for
the management of GBM. In this article, we review the molecular characterization of GBM cells
and current treatment strategy, including gross or near-total resection of the tumor, followed
by radiotherapy and concurrent chemotherapy, stereotactic brachytherapy and new targeted
therapies. Th e multimodal approaches for the treatment of GBM improve the prognosis.
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