alexa Molecular Follow Up Of Patient With Preneoplastic Lesion That Progress To Cervical Cancer Locally Advanced | 9760
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Translational & Personalized Medicine

Pablo Moreno-Acosta
Accepted Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.010
Abstract
Introduction: We report a case of squamous cell carcinoma of the uterine cervix stage IIIB with 16 years of progression. Case: A 43-year old woman was diagnosed with a high-grade squamous intraepithelial lesion of uterine cervix (HGSIL) in 1986. There were several colposcopy and directed biopsies, with changes consistent with HGSIL and HPV infection. The gynecologist meeting decides that the patient should be treated by means of an abdominal extended hysterectomy, being sent to another hospital for definitive treatment. Due administrative problems she was never treated. She returned to the National Cancer Institute on September of 2002 with a tumor of size of 5 cms, and is diagnosed with squamous cell carcinoma of the uterine cervix IIIB. She begins exclusive radiotherapy but abandoned and died in 2005. Methods: Analysis of molecular markers was performed on biopsies taken in 1986 and 2002 respectively. Results: HPV16 E6 E-r and AA mixed variants were detected in samples took in 1986. A HPV16 E-r and AAc variant was detected in 2002, which could indicate the persistence of the infection. Polymorphism analysis of Arg72Pro p53 in 1986 and 2002 showed an Arg/Pro genotype respectively. An increment of expression of anti-apoptotic, glycolytic and hypoxic markers, IGF1R, Survivin, GLUT1, and CAIX, was observed in 2002 compared with the analysis done 1986. Conclusions: The progression of cervical lesions to invasive cancer can be avoided by the use of molecular profiling analysis, ensuring early diagnosis and better therapeutic management that could include molecular targets.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

geneticsmo[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

streamtajm

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version