alexa Molecular Mechanism And Intervention Studies Of Regenerative Mossy Fiber Sprouting In Hippocampus Following Developmental Seizures
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

JOINT EVENT on 11th International Conference on Clinical Pediatrics & 2nd International Conference on Pediatric Surgery
June 29- July 01, 2017 London, UK

Ni Hong
Soochow University, China
Posters & Accepted Abstracts: Pediatr Ther
DOI: 10.4172/2161-0665-C1-040
Developmental seizure-induced brain damage can cause serious neurological sequelae. Denervation and regenerative mossy fiber (MF) sprouting in the hippocampal dentate gyrus and CA3 subfields are the main neuroanatomical bases. We used several developmental epilepsy animal models to study the mechanism of seizure-induced mossy fiber sprouting and intervention strategy. We found that recurrent prolonged developmental seizures induced by penicillin or inhalant flurothyl can cause long-term cognitive deficit and hippocampal regenerative sprouting in adulthood, which is in parallel with long-term significantly up- or down-regulated expression of zinc transporters (ZnT1, ZnT3, ZIP6), plasma membrane damage associated-lipid metabolism molecules (PRGs, Cyp46a1, cPLA2, ACAT1, nSMase, Kcnj11, Lepr, Drd2, Mc4r, Apoa1, Oprk1, Pdk4, ApoE) and autophagy markers (beclin-1, LC3, p62, cathepsin E) in the hippocampus. Moreover, there were significant correlation among autophagic, Zn transporter signaling and lipid metabolism molecules. Ketogenic diet, plasma membrane oxidant injury protectant melatonin, lipid metabolism regulating molecule leptin, autophagy inhibitors (3-MA, CBI, E-64d), as well as early physical exercise were able to restore the abnormal expressions to normalize and alleviate the aberrant hippocampal MF sprouting, neurobehavioral and cognitive changes, which may be achieved through cPLA2/drp1/autophygy pathway, and by regulating the expression of Zinc/CaMK II signaling. Our study will be helpful for exploring the target genes of axonal regeneration following developing seizures from a new point of view and will contribute the efforts for making proper early intervention, as well.

Email: [email protected]

image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version