alexa Molecular Mechanisms Underlying Insulin Resistance In Skeletal Muscle During Catch-up Growth | 22083
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Endocrinology

Juan Zheng, Lulu Chen, Xiang Hu and Chaodong Wu
ScientificTracks Abstracts: Endocrinol Metab Synd
DOI: 10.4172/2161-1017.S1.005
Abstract
Nutritional recovery after malnutrition produces a phase of rapid growth following a temporary period of growth retardation, which is termed as catch-up growth (CUG). The CUG phenomenon has been implicated as a predisposing factor for the development of insulin resistance (IR) and related diseases, especially in Asian populations. Our group inducted CUG in rats by 60% caloric restriction (CR) for a time period of 4 weeks and followed by normal chow re-feeding for an additional 8 weeks. Catch-up growth-induced IR was evidenced by significant reductions in both average glucose infusion rate under euglycemia clamp and skeletal muscle glucose uptake. During CR, activity of complexes I, III, and IV was decreased and activity of complex II was increased in skeletal muscle. After re-feeding, activities of complexes I to IV in the CUG group and mitochondrial citrate synthase were significantly lower than their respective activities in the NC group. In contrast, reactive oxygen species levels were significantly higher and activities of antioxidant enzymes were significantly lower in intermyofibrillar and SS mitochondria of skeletal muscle than those, respectively, in the NC group. Additionally, the activity of silent information regulator 1 (SIRT1), along with the expression of genes related to mitochondrial biogenesis (PGC-1α, NRF-1, and mtTFA), was reduced after CR, and remained low upon re-feeding. In contrast, the gene for lipid transportation, FAT/CD36, was up-regulated after re-feeding. In a parallel study, resveratrol (an activator of Sirt1) supplementation or SIRT1 overexpression was shown to increase SIRT1 activity and prevent decreases in activities of complexes I, III, and IV during CR, which were accompanied by improved mitochondrial biogenesis and insulin sensitivity in CUG rat after re-feeding. Together, these results suggest that the impaired insulin sensitivity in CUG rats was associated with decreases in subsarcolemmal and intermyofibrillar mitochondria, increases in mitochondrial redox level, and impaired activity of antioxidant enzymes and complexes I to IV in mitochondria.
Biography
Juan Zheng received her MD and PhD from Tongji Medical College, Huazhong University of Science and Technology. In December 2012, she started her postdoctoral training at University of Toronto. Currently, she is continuing her postdoctoral training at Texas A&M University. Her research is focused on nutrition and insulin resistance related metabolic diseases. She is the principal investigator on grants funded by the national natural science foundation of China (NSFC) and China international medical foundation (CIMF).
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

https://www.gaziantepescort.info

James Franklin

eng[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version