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Molecular Sensing Based On Optical Whispering-gallery Mode Microsensors | 6417
ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
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Molecular sensing based on optical whispering-gallery mode microsensors

2nd International Conference and Exhibition on Biosensors & Bioelectronics

Zhixiong Guo

Accepted Abstracts: J Biosens Bioelectron

DOI: 10.4172/2155-6210.S1.022

In this plenary talk, we will discuss optical whispering-gallery modes (WGM) resonance and its applications in nanoscale detection and molecular level sensing. The sensing principle is either an evanescent electromagnetic field interacts with target biomolecules adsorbed or covalently attached to the microsensor surface or a resonant field interacts with target molecules trapped inside a resonator, and consequently induces changes in the optical resonance spectrum. For example, a porous ring microresonator integrated in a micro electrofluidic system can function as both a filter and an optical WGM sensor. The microelectrofluidic forces augment substantially the filtration capability of the system, which separates the target molecules from solution and enriches the analyte deposition inside the porous resonator. This alters the optical properties of the resonator and shifts the optical WGM resonance frequency, leading to potential label-free ultrasensitive detection of small molecules at picomolar concentration levels and below.
Zhixiong Guo is a Professor at Rutgers, The State University of New Jersey, and a Fellow of American Society of Mechanical Engineers. He holds a doctorate in both Engineering Physics and Mechanical Engineering. His specialty lies in the modeling and experimental analysis of radiation-matter interactions and applications in nanoscale optical sensing, lasers in biomedicine, and thermal management. He proposed detection of single bio/ chemical molecules using optical whispering-gallery modes. He has published more than 70 papers in reputed journals and serving as an associated editor and editorial board member of repute.