Molecular Sensing Based On Optical Whispering-gallery Mode Microsensors | 6417
Journal of Biosensors & Bioelectronics
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In this plenary talk, we will discuss optical whispering-gallery modes (WGM) resonance and its applications in nanoscale detection
and molecular level sensing. The sensing principle is either an evanescent electromagnetic field interacts with target biomolecules
adsorbed or covalently attached to the microsensor surface or a resonant field interacts with target molecules trapped inside a resonator,
and consequently induces changes in the optical resonance spectrum. For example, a porous ring microresonator integrated in a micro
electrofluidic system can function as both a filter and an optical WGM sensor. The microelectrofluidic forces augment substantially the
filtration capability of the system, which separates the target molecules from solution and enriches the analyte deposition inside the
porous resonator. This alters the optical properties of the resonator and shifts the optical WGM resonance frequency, leading to potential
label-free ultrasensitive detection of small molecules at picomolar concentration levels and below.
Zhixiong Guo is a Professor at Rutgers, The State University of New Jersey, and a Fellow of American Society of Mechanical Engineers. He holds a
doctorate in both Engineering Physics and Mechanical Engineering. His specialty lies in the modeling and experimental analysis of radiation-matter
interactions and applications in nanoscale optical sensing, lasers in biomedicine, and thermal management. He proposed detection of single bio/
chemical molecules using optical whispering-gallery modes. He has published more than 70 papers in reputed journals and serving as an associated
editor and editorial board member of repute.
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