alexa
Reach Us +447482876457
Multi-layer Scaffolds For Heart Valve Tissue Engineering | 5380
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Multi-layer scaffolds for heart valve tissue engineering

International Conference on Tissue Science & Engineering

Jan T Czernuszka and Qi Chen

Accepted Abstracts: J Tissue Sci Eng

DOI: 10.4172/2157-7552.S1.008

Abstract
N ative heart valve has the fibrosa-spongiosa-ventricularis tri-layer structure, with the main extracellular matrix (ECM) material of each layer being collagen, glycosaminoglycans (GAGs), and elastin respectively. It is because of this layered structure that the heart valve exhibits a flexural anisotropy, that is, it is easier to bend towards the ventricularis side (VS) (known as ?with curvature?) than towards the fibrosa side (known as ?against curvature?). In this present study, a bi-layer structure was introduced to the scaffolds for heart valve tissue engineering, with one layer rich in collagen and the other rich in elastin. Flexural properties of the bi-layer scaffolds were examined by three-point bending tests, which showed that the scaffolds had anisotropic bending modulus (21.9?4.1 kPa with curvature VS 39.3?3.6 kPa against curvature). A finite element approach (ANSYS) was used here to simulate the three-point bending tests, and had been in good agreement with the experimental data. Simulated bending tests with distributed loading were performed, and showed that the bi-layer scaffold would have a 0.4mm difference in the deflection under 500 Pa, depending on which direction it was bent. Internal stress analysis found that there was a higher shear stress (~800 Pa) at the layer interface than in the region less close to it (~400 Pa). The findings of this work served as a step forward to the tri-layer scaffold, and also provided guidance for better designing a mechanically qualified scaffold for heart valve tissue engineering
Biography
Leave Your Message 24x7
Top