Myc-p53 Interactions Illustrate A Paradigm For Coupled Oncogene-tumor Suppressor Dynamic Control Of Cancer Development | 9360
Journal of Computer Science & Systems Biology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Myc and p53 are both transcription factors, each affecting the expression of thousands of genes. Two recent census of
human cancer genes list Myc and p53 in the top groups of frequently amplified and mutated genes, respectively. Myc is an
oncogene that promotes cell proliferation and inhibits cell differentiation, whereas p53 is a tumor suppressor gene that inhibits
proliferation and promotes differentiation. We have summarized the published literature on pathways of interactions between
Myc and p53; and we show that most of the pathways form negative feedback loops (i.e., Myc upregulates p53 activity while
p53 downregulates Myc). In many cancers, however, positive feedback interactions (i.e., mutual antagonism) between Myc and
p53 may predominate. I will discuss how one can quantify the strengths of the positive and negative feedback loops, thereby
allowing us to make predictions on how to control Myc activity. I will also give other examples of oncogene-tumor suppressor
gene interactions and argue for the proposal that cancer therapy should be designed in the context of controlling the network of
interactions between oncogenes and their associated tumor suppressor genes.
Aguda obtained his Ph.D. in Chemistry (Chemical Physics Program) and was a faculty member of a few Canadian and US universities before he re-
focused his research program on cancer systems biology and moved to NCI in 2010. Some of his substantial contributions include the development
of predictive network and kinetic models of mammalian cell cycle checkpoints such as the Restriction Point and the G2 DNA Damage Checkpoint
Pathway. He and Professor Avner Friedman wrote the graduate-level book
Models of Cellular Regulation
published in 2008 by Oxford University
Press. At the NCI, He works in the field of network pharmacology.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals