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Chemokines are small secreted proteins with chemoattractant properties that play a key role
ammation, metastasis, and embryonic development. We previously demonstrated
a nonchemotactic role for one such chemokine pair, stromal cell-derived factor-1α and its
G-protein coupled receptor, CXCR4. Stromal cell-derived factor-1/CXCR4 are expressed on
cardiac myocytes and have direct consequences on cardiac myocyte physiology by inhibiting
contractility in response to the nonselective β-adrenergic receptor (βAR) agonist, isoproterenol.
As a result of the importance of β-adrenergic signaling in heart failure pathophysiology, we
investigated the underlying mechanism involved in CXCR4 modulation of βAR signaling.
Our studies demonstrate activation of CXCR4 by
stromal cell-derived factor-1 leads to
a decrease in βAR-induced PKA activity as assessed by cAMP accumulation and PKA-
dependent phosphorylation of phospholamba
n, an inhibitor of SERCA2a. We determined
CXCR4 regulation of βAR downstream targets is β2AR-dependent. We demonstrated a
physical interaction between CXCR4 and β2AR as determined by coimmunoprec
confocal microscopy, and BRET techniques. We assessed the eff
ect of cardiac overexpression
of CXCR4 during TAC using a cardiotropic adeno-associated viral vector (AAV9) carrying the
wildtype CXCR4 gene (AAV9.CXCR4
). Cardiac overexpression of CXCR4
in mice with
pressure overload prevented ventricular remodeling and maintained function as determined
by echocardiography and in vivo hemodynamics. Th
e CXCR4 interaction with β2AR will
provide further insight into how CXCR4 modulates calcium homeostasis and chronic pressure
overload responses in the cardiac myocyte. Together these results suggest that AAV9.CXCR4
gene therapy is a potential therapeutic approach for congestive heart failure
Dr. Sima Tarzami received her B.Sc. and M.Sc. degrees from Hofstra University, New York, and her Ph.D. from
Albert Einstein School of Medicine, New York, all in USA from 1992-2002. She has been a faculty in Mount Sinai
School of Medicine since 2007, fi rst as a Research Instructor and then promoted to an Assistant Professor of
Medicine. Her major area of research is related to myocardial expression, signaling and function of chemokine
receptor-4 in the animal models of heart disease. She currently holds a Grant in Aid from the American Heart
Association, and KO2 from the NIH. She is an author of 14 peer reviewed papers and 10 published abstracts.
She is a member of editorial board of international journal of clinical and experimental medicine (IJCEM) and
also a manuscript reviewer of number of major journals including AHA.
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