alexa Nanodrug Delivery Of A Multimodal Novel Drug Cerebrolysin Reduces Engineered Nanoparticles Induced Aggravation Ofheat Stroke Induced Ubiquitin Expression And Brain Pathology
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference on Nanotek & Expo
December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Hari S Sharma, Dafin F Muresanu, Jose Vicente Lafuente, Ranjana Patnaik, Z Ryan Tian, Herbert M?ssler, Aruna Sharma
ScientificTracks Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.017
Abstract
Accumulation of ubiquitin within the brain after trauma leads to neurodegenerative changes or brain pathology. Our previous reports show that acute heat exposure leads to breakdown of the blood-brain barrier (BBB) resulting in edema formation and cellular injury. Thus, military personnel engaged in combatoperations in summer heat and prone to silica dust (SiO2 nanoparticles) exposure may result in exacerbation of their brain dysfunction. Since ubiquitin expression is increased following CNS injurywe examined ubiquitin expression in brain following SiO2 exposurein heat stress in rats. Furthermore, neuroprotective efficacy of cerebrolysin, a multimodal drug with pleotropic activity due to several neurotrophic factors and active peptide fragment on ubiquitin expression was also evaluated in these conditions. Our observations show that rats subjected to 4 h heat stress in a Biological Oxygen Demand incubator (BOD) resulted in over expression of ubiquitin in several brain areas (+40 to 120 %) from control group. Chronic SiO2 intoxication (50-60 nm, 50 mg/kg, i.p. daily for 7 days) resulted in exacerbation of ubiquitin accumulation by further 150 to 260% in the identical brain areas following heat exposure. Cerebrolysin in low doses reduced the ubiquitin expression in heat stress but required high doses or TiO2 nanowired delivery to have similar effectsin SiO2 intoxicated group. These observations are the first to suggest that (i) ubiquitin expression in the brain following heat stress is involved in neuronal damages, (ii) that is further exacerbated by SiO2 intoxication, (iii) and cerebrolysin downregulates ubiquitin expression to induce neuroprotection, not reported earlier.
Biography
Hari S Sharma is the Director of Int. Experimental CNS Injury Research & Repair, University Hospital, Uppsala University, Sweden. He is actively engaged on research in brain injuries, blood-brain barrier and brain edema since last 30 years. He received the 1st US Neurosurgeon Anthony Marmarou Brain Edema award by the International Brain Edema Society, Tokyo, Japan in October 2011 and Top Innovation Award on ?Nanowired cerebrolysin for neuropathic Pain? at National Innovation & Showcase Summit Washington DC, USA May 12-16, 2013. He published over 350 research papers in reputed Neuroscience journals.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version