alexa Nanoencapsulated Phytochemicals Based Gold Nanoparticles And Their Application In Nanomedicine
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Materials Science & Engineering
October 06-08, 2014 Hilton San Antonio Airport, USA

Menka Khoobchandani, Kavita Katti and Kattesh V Katti
Accepted Abstracts: Material Sci Eng
DOI: 10.4172/2169-0022.S1.017
Abstract
Nanotechnology based therapeutics and imaging represent a new platform for treatment and diagnostics. Despite the versatility of nanomedicine based therapies, it is important to develop the cost effective nanoparticles with more efficacy and less side effect. Our laboratory focuses on the Green Nanotechnology, where we develop the nanoparticles from naturally occurring phytochemicals. Nanoencapsulation of phytochemicals based formulations has shown great promise in enhancing drug efficacy, increasing drug tolerance, and improving targeted drug delivery. Among the other, gold nanoparticles possess a tremendous opportunities for the next generation bio-agent. Herein, we comprehensively develop the nanoparticles from phytoextract and their phytochemicals by simple mixing with gold salt. We explored the synthesis and characterization of phytoextract and their phytochemicals based gold nanoparticles and their anticancer activity against metastatic breast and prostate cancer cell line and their cellular internalization. We have explored various plant extract like broccoli, tea leaves, and mango peel. These plant extracts showed the presence of most promising phytochemicals like mangiferin in mango peel, isothiocyantes and glucosinolates in broccoli and EGCG in green tea. The synthesis of phytochemicals conjugated nanoparticles was confirmed by various spectroscopic techniques like UV visible, transmission electron microscope, atomic absorption spectrometry, and the size was confirmed by dynamic light scattering instrument. We showed that nanoparticles treatment resulted in decreased cell viability and suppression of metastatic potential in terms of migration and invasion in metastatic cancer cells. Among the other, mangiferin conjugated nanoparticles induce down regulation of NFkB factor and induce apoptosis in the cancerous cells. These findings suggest that phyto chemicals based gold nano particles might be a very promising candidate for cancer intervention and prevention.
Biography
Menka Khoobchandani has completed her PhD at the age of 26 years from Dayalbagh Educational Institute, Dayalbagh, Agra, India. She is a Postdoctoral researcher at Department of Radiology and Cardiovascular Medicine, University of Missouri, Columbia, MO, USA. She has published more than 10 papers in reputed journals and presentation to her credit. She has filled one patent through a recent discovery on Cardiotherapeutic nanopharmaceuticals - A new alternative to drug coated stents.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version