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Drug targeting and enhancing the bioavailability of poorly water soluble drugs by an effective drug delivery system has been
a dream for a long time. Designing of effective drug delivery system by using nanotechnology has gained importance in
recent times. Nanosponge is one of such effective drug delivery system which overcome the problems of drug toxicity and poor
bioavailability. Nanosponges are innovative carriers which are about a size of a virus with a 3-dimensional network or scaffold
structure and a nanometric cavity size. These can act as the carriers for several hydrophilic and lipophilic drugs which have poor
aqueous solubility. The backbone is a long length of polyester which is mixed in solution with small molecules called cross-linkers
that act like tiny grappling hooks to fasten different parts of the polymer together. The net effect is to form spherically shaped
particles filled with cavities where drug molecules can be stored. By the attachment of specific peptide linkers, nanosponges are
targeted to specific sites in the body thus minimize the adverse effects and increase the efficiency of the drug. It holds a promising
future in various pharmaceutical applications in the coming years like enhanced product performance and elegancy, extended
release, reduced irritation, improved thermal, physical, and chemical stability of product. In this review, an attempt is made to
summarize the methods of development, characterization, applications and future of this innovative carrier system.
Mamidi Hemanth Kumar completed Bachelors in Pharmacy from JNTU- Hyderabad and now he is pursuing his Masters in Pharmacy (second
semester) from Anurag group of institution, School of Pharmacy.
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