alexa Nasal Colonization And Antimicrobial Susceptibility Pattern Of Staphylococcus Aureus Among Pre-school Children In Ethiopia
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
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JOINT EVENT ON 15th International PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY CONFERENCE & 10th Annual MEDICAL MICROBIOLOGY SUMMIT & EXPO
June 21-23, 2017 London, UK

Alemayehu Reta
Debre Markos University, Ethiopia
Posters & Accepted Abstracts: J Med Microb Diagn
DOI: 10.4172/2161-0703-C1-006
Abstract
Background: Staphylococcus aureus is one of the bacterium that can asymptomatically colonize the human upper respiratory tract (i.e. nose and throat). Carriage of S. aureus, including methicillin resistant Staphylococcus aureus, is common to children. Objective: The aim at this study was to determine the nasal colonization, associated factors and antimicrobial susceptibility patterns of Staphylococcus aureus isolates among pre-school children in Debre Markos town. Methodology: Institutional-based cross sectional study was conducted. A total of 400 nasal swabs were collected from pre-school children from April to June, 2015 following standard microbiological methods. MRSA was detected using both cefoxitin (30 μg) and oxacillin (6 μg) discs in combination and associated factors were assessed using self-administered pretested questionnaires, which were delivered to the children’s parents/guardians. Statistical analysis of the data (logistic regression) was done using SPSS V-22. Results: A total of 52 Staphylococcus aureus isolate was recovered from 400 nasal swap samples. The prevalence of S. aureus among pre-school children was 13% (52/400). The susceptibility patterns of the isolates to commonly used antibiotics were: 84.62% to chloramphenicol, 69.2% to doxycycline and tetracycline, 92.3% to kanamycin, 7.7% to ampicillin and penicillin, 86.6% to ceftriaxone, and 76.9% to augmentin. All the isolates were sensitive to oxacillin and cefoxitin; there was no methicillin resistant Staphylococcus aureus isolate, and also sensitive to gentamycin, erythromycin and clindamycin. The main associated factors of nasal colonization of S. aureus in the study area was having recurrent acute otitis media [AOR=2.37(1.11, 5.06)], children admission in hospital [AOR=1.96(1.03, 3.73)] and cough [AOR=2.09(1.08, 4.09)]. Conclusion & Recommendation: The prevalence of S. aureus nasal colonization among pre-school children was relatively low and there was no MRSA isolate. Factors like; recurrent acute otitis media, hospital admission and cough were significantly associated with S. aureus nasal colonization. Most of the isolates were resistant to β-lactam drugs and sensitive to drugs like gentamycin, erythromycin, clindamycin, chloramphenicol, doxycycline, tetracycline, kanamycin and augmentin. Hence, the isolates in the community may disseminate to the hospital environment, we should not give β-lactam drugs unless we perform antimicrobial susceptibility test for treatment of any infection caused by S. aureus.
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