alexa Natural Compound Derived Z-ajoene Decreases NOTCH Signaling In U87-derived Glioblastoma Cancer Stem Cell
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Cell & Gene Therapy
October 27-29, 2014 Embassy Suites Las Vegas, USA

Yuchae Jung, Heejoo Park, Raok Jeon, Jeaha Rhyu and Wooyoung Kim
ScientificTracks Abstracts: J Stem Cell Res Ther
DOI: 10.4172/2157-7633.S1.007
Abstract
Glioblastoma multiform (GBM) is the most common brain tumor and the GBM patients have a poor prognosis with median survival of one year. Recent evidence suggests the presence of cancer stem cell (CSC) in GBM and it is expected that rare CSC subpopulation is resistant to chemotherapy and may lead to recurrence and metastasis. CSCs can self-renew such as normal stem cell and have highly tumorigenic property. In this study, natural compounds including Z-ajoene with anti-CSC effect was screened and it was observed that Z-ajoene has anti-CSC effect. Although Z-ajoene is known to have antitumor effects, but its mechanism is not clearly understood yet. In this study, putative mechanism through focusing on selfrenewal pathways associated with survival and maintenance of CSCs was examined. Z-ajoene decreased the transcript level of Notch, Wnt, TGFβ, and PI3K/AKT pathways which is related with stemness and maintenance of CSCs while Z-ajoene showed elevated activity of ERK and P38 pathway is related with cellular stress. These results suggest that Z-ajoene can be an anti-CSC drugs which has less side effects and cytotoxicity.
Biography
Yuchae Jung has completed her PhD at the age of 30 years from Catholic University majoring in Computational Biology. She did her Postdoctoral studies from Brigham and Women?s Hospital working on the relationship between glioblastoma and cooperative miRNAs. She continued to work on the relationship between GBM cancer stem cells with miRNA profiles supported by Korean National Research Foundation grant. She has published more than 12 papers in reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords