Neuroprotective Role Of Vitamin D In Primary Cortical Neuronal Cultures | 75583
Journal of Neurology & Neurophysiology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
A role of vitamin D in brain development and function has been gaining support over the last decade. There are several lines of
evidence that suggest vitamin D may have a neuroprotective role. The administration of vitamin D or its metabolites has been
shown to reduce neurological injury and/or neurotoxicity in a variety of animal systems. Physiological concentration of calcidiol and
calcitriol is between 30-50 nM in blood whereas the physiological concentration in brain is found to be 10 pM. This vitamin can cross
the BBB and bind to the nuclear D3 receptors in the brain. Preliminary studies in our laboratory indicated that when isolated primary
neuronal cells derived from rat’s brain were pre-treated with vitamin D and then followed by induced oxidative stress with hydrogen
peroxide, it resulted in greater neuroprotection by upregulating the gene expression of glutathione. The research in our laboratory
looked at various metabolic markers of oxidative stress and apoptosis, and found that pretreatment of neurons for upto six days
with vitamin D3 can significantly reduce lipid peroxidation as well as protecting genomic DNA oxidation by hydrogen peroxide. A
number of criteria for looking at cell viability and proliferation in the presence of vitamin D3 treatments were employed and it again
showed better protection of the neurons from induced oxidative stress, suggesting its potential role as a neuro therapeutics agent.
Our results highlight the importance of taking vitamin D3 supplements from an early age which could prevent the development of
various neurodegenerative diseases.
Samina Hyder Haq is a Senior Biochemist by profession, having completed a Doctorate in Biochemistry from the Medical School, University of Manchester, United Kingdom. She is very experienced in Biochemistry and Molecular Biology fields. She has worked with the Connective Tissue Research Group (UK) where most of the pioneering work was done in the collagen field. Her research at the Medical School Manchester (UK) developed and excelled in tissue culture techniques to study collagen synthesis in cultured avian and mammalian cells. She is currently working as an Assistant Professor at Biochemistry Department King Saud University. Her main research interest is using primary neuronal cultures as a model for various neurogenerative disorder and looking at the therapeutic efficacy of various drugs.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals