alexa New Biopolymer From Comfrey: Chemistry And Biological Activity | 72053
ISSN: 2157-7048

Journal of Chemical Engineering & Process Technology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

JOINT EVENT ON 5th International Conference on Bioplastics and 6th World Congress on Biopolymers

Maia Merlani, Vakhtang Barbakadze, Lela Amiranashvili and Lali Gogilashvili
Tbilisi State Medical University, Georgia
ScientificTracks Abstracts: J Chem Eng Process Technol
DOI: 10.4172/2157-7048-C1-005
Abstract
Comfrey root has been used as a traditional medicinal plant for the treatment of painful muscle and joint complaints for centuries. Recently, biologically active polymer has been isolated from Caucasian species of comfrey Symphytum asperum Lepech. and S. caucasicum Bieb. This polymer - poly[3-(3,4-dihydroxyphenyl)glyceric acid] (p-DGA) is a representative of a new class of natural polyethers with a residue of 3-(3,4-dihydroxyphenyl)-glyceric acid (DGA) as the repeating unit. P-DGA exhibits high antioxidant, anti-inflammatory, wound healing and anticancer activities. In order to compare biological properties of natural polymer with its synthetic analogues, racemic and pure enantiomeric forms of DGA as well as a methylated analogue of p-DGA - poly(MCDMPO) as a precursor of p-DGA were synthesized. The racemic monomer and its virtually pure enantiomers were synthesized via Sharpless asymmetric dihydroxylation of trans-caffeic acid derivatives using an potassium osmiate catalyst, a stoichiometric oxidant N-methylmorpholine-N-oxide and enantio-complementary catalysts cinchona alkaloid derivatives (DHQ)2-PHAL and (DHQD)2-PHA as chiral auxiliaries. Poly(MCDMPO) was obtained via ring opening polymerization of 2-methoxycarbonyl-3-(3,4-dimethoxyphenyl)-oxirane (MCDMPO) using a cationic initiator. Comparative investigation of antioxidant properties of natural polymer and its monomer revealed that the latter appeared 40 fold active than polymer, however anticancer efficacy of p-DGA against human prostate cancer (PCA) cells is more compared to its synthetic monomer. Poly(MCDMPO) did not show any activity against PCA.
Biography

Maia Merlani has completed her PhD from Tbilisi State University. She is a Senior Research Scientist at Tbilisi State Medical University, Department of Plant Biopolymers. Her field of interest is a Chemistry and synthesis of Natural Compounds. She is the author of more than 55 papers in reputed journals and presentations at 60 international scientific conferences. She was granted Georgian Presidential Scholarship for Young Scientists (1997), NATO Scholarship (2002, 2003-2006) and Matsumae International Foundation Scholarship (2013). She is a member of organizing committee of several international conferences in the field of Organic and Pharmaceutical Chemistry.

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

https://www.gaziantepescort.info

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version