alexa New Nanoscale Fluorescent Method For Analysis Of Quality Of DNA Double Helix | 60879
ISSN: 2471-8556

Oncology & Cancer Case Reports
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

15th World Congress on CANCER THERAPY, BIOMARKERS & CLINICAL RESEARCH
December 05-07, 2016 Philadelphia, USA

T. G. Giorgadze, I G Khutsishvili, Z. G. Melikishvili, T. B. Khuskivadze, K. I. Sigua and V. G. Bregadze
Ivane Javakhishvili Tbilisi State University, Georgia
Georgian Technical University, Georgia
Ilia Chavchavadze State University, Georgia
Posters & Accepted Abstracts: Oncol Cancer Case Rep
DOI: 10.4172/2471-8556.C1.003
Abstract
The goal of this work is using the method of laser - induced fluorescence resonance energy transfer (FRET) of electronic excitation in the donor-acceptor pair of intercalators, (acridine orange as a donor and ethidium bromide as an acceptor), for quantitative analysis of the quality of DNA double helix. The approach allows getting a visual picture of the defects of genetic apparatus of tissue cells, particularly of skin cells in real time and it can be used for diagnosis of skin diseases, also in cosmetology. Transition metal ions such as Cu(II), Cu(I), Ag(I), silver nanoparticles (AgNPs), photo- and thermo effects were used to cause double helix defects in DNA. Concentration of DNA sites, which are applicable for intercalation, after the exposure to Cu(II), Cu(I), Ag(I) ions, AgNPs impact as well as laser irradiation (λ = 457 nm) and temperature, which are applicable for intercalation, were estimated in relative units. The nanoscale FRET method allows estimation of the concentration of double helix areas with high quality stability applicable for intercalation in DNA after it was subjected to stress effect. It gives the opportunity to compare DNA-s of 1) different origin; 2) with various damage degrees; 3) being in various functional state.
Biography

Tamar Giorgadze is a Scientist at the department of biological systems of physics, Andronikashvili Institute of Physics. She has completed her PhD at the age of 30 years from St. Andrew The First-Called Georgian University of The Patriarchate of Georgia. She is author of 9 scientific publications.

Email: [email protected] [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version