alexa New Synthetic Route For Preparation Of Cis (-) Nucleosides | 68977
ISSN: 2161-0401

Organic Chemistry: Current Research
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3rd International Conference on Organic and Inorganic Chemistry

Devender Mandala and Paul Watts
Nelson Mandela Metropolitan University, South Africa
Posters & Accepted Abstracts: Organic Chem Curr Res
DOI: 10.4172/2161-0401-C1-020
Abstract
Cis-nucleoside derivatives lamivudine (3TC) and emtricitabine (FTC) are useful in the treatment of retroviral infections caused by human immune deficiency virus (HIV), Hepatitis B virus (HBV) and Human T-Lymotropoic virus (HTLV). Lamivudine and emtricitabine are potent nucleoside analogue reverse transcriptase inhibitors (nRTI). These two drugs are synthesized by a four-stage process from the starting materials: Menthyl glyoxylate hydrate and 1,4-dithane-2,5-diol. All reagents and intermediates have been tested satisfactorily. Pharmaceutical development has been adequately described and also it has been shown as the most thermodynamically stable form. Although there are several different methods reported for the synthesis of lamivudine and emtricitabine as a single enantiomer, we required an efficient route, which was suitable for largescale synthesis to support the development of these compounds. In this process, we successfully prepared the intermediates of lamivudine and emtricitabine without using any solvents and catalyst, thus promoting the green synthesis.
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