alexa Nigella Sativa Oil Ameliorates The Effect Of Cisplatin On Brush Border Membrane Enzymes And Antioxidant System In Rat Intestine | 14337
ISSN: 2327-5162

Alternative & Integrative Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference and Exhibition on Traditional & Alternative Medicine

Faaiza Shahid
Posters: Altern Integ Med
DOI: 10.4172/2327-5162.S1.003
Abstract
Cisplatin (CP; cis-diamminedichloroplatinum II) is a major antineoplastic drug effective against a broad spectrum of malignancies. Patients receiving CP, however, experience very profound and long lasting gastrointestinal symptoms. Nigella sativa seeds/oil has been used in a wide range of gastrointestinal disorders. In view of this, the present study investigates the protective effect of Nigella sativa oil (NSO) on CP-induced adverse biochemical alterations in the small intestine of rat. Rats were divided into four groups, the CP+NSO and NSO groups were administered NSO (2 ml/kg b.wt orally), with or without single dose of CP treatment (6 mg/kg b. wt. i.p) respectively. Serum parameters, activities of brush border membrane (BBM) enzymes and various oxidative stress parameters were analysed in mucosal homogenates and/or brush border membrane vesicles (BBMV). CP treatment caused significant decline in the activities of alkaline phosphatase (ALP), γ-glutamyltransferase (GGTase), leucine aminopeptidase (LAP) and sucrase both in the mucosal homogenates and in the isolated brush border membrane vesicles (BBMV). However, the CP induced decrease in the activities of ALP, GGTase, LAP and sucrase was significantly prevented when CP treatment was extended to NSO administered rats. Lipid peroxidation and total sulfhydryl groups were altered upon CP treatment. CP significantly decreased the activities of SOD, catalase, GSH-Px, GR and TR. The CP induced changes in the activities of SOD, CAT and GSH-Px, GR and TR were ameliorated when CP treatment was given to NSO fed rats. The results suggest that NSO owing to its intrinsic biochemical/antioxidant properties enhanced resistance to CP elicited adverse gastrointestinal effects. Keywords: Cisplatin, brush border membrane, Nigella sativa oil , intestine, and oxidative stress
Biography
Faaiza Shahid is pursuing Ph.D. from Department of Biochemistry, A.M.U, Aligarh. She is presently working on ?Protective effect of Nigella sativa oil on cisplatin induced intestinal toxicity?.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7