alexa Nitric Oxide Inhibitor Effect On TNF-α In Transient Cerebral Ischemia And Reperfusion In Rats
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Translational & Personalized Medicine
August 05-07, 2013 Holiday Inn Chicago-North Shore, IL, USA

Amal Mahmoud Saeed
Accepted Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.010
Abstract
Stroke is the second cause of death and a frequent cause of disability globally. Pro-inflammatory tumor necrosis factor-α (TNF-α) is elevated after cerebral infarction in human brain; and the interaction between TNF-α and Nitric Oxide (NO) in cerebral ischemia/reperfusion (I/R) is still doubtful. The aim of this work was to examine the relation between TNF-α and nonselective Nitric Oxide synthase (NOS) inhibitor (N-nitro-L-arginine-methylester (L-NAME)) on rats subjected to transient focal cerebral I/R. 30 adult male Wistar rats divided into three groups 10 rats in each: First group was Sham-operated and served as a control, I/R group of rats infused with 0.9% normal saline intraperitoneally 15 minutes prior to 30 minutes of left common carotid artery (CCA) occlusion; then allowed for reperfusion for 24-hour. A test group infused with L-NAME intraperitoneally 15 minutes prior to the same I/R period. Neurobehavioral assessments were evaluated using six tests. Quantitative assessment of TNF-α using ELISA method; NO metabolites (nitrite, nitrate) in both serum and the affected cerebral hemisphere were done. The L-NAME group showed a significant improvement in neurological deficit compared to both I/R and control groups (P<0.001). The serum and brain tissue of TNF-α and NO were significantly increased in I/R group compared to the control group, while L-NAME administration resulted in a significant decrease in TNF-α and NO compared to the I/R group(P<0.001). These data demonstrated that L-NAME significantly improves neurological deficit and shows a potential neuroprotection through reducing TNF-α in a rat?s model of transient focal cerebral ischemia reperfusion.
Biography
Amal Mahmoud Saeed is the head of physiology department Faculty of Medicine/University of Khartoum1996-2004, Vice Dean of Graduate College for Post Graduate Medical Health Sciences 2003-2006 and Director of Educational Development Centre for Health profession 2006 -2008. Now she is the President of the Sudanese Physiological Society and African Physiological society and a member of the educational committee in the International Union of Physiology.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version