alexa Non-communicable Disease Comorbidities And Treatment Outcomes Among People Living With Human Immunodeficiency Virus On Highly Active Anti-retroviral Therapy At Jimma University Specialized Hospital, South West Ethiopia: Nested Case-control Study
ISSN: 2167-0870

Journal of Clinical Trials
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

6th World Pharmacists and Clinical Pharmacy Annual Congress
May 22-23, 2017 Chicago, USA

Tsegaye Melaku Kebede, Girma Mamo, Legese Chelkeba and Tesfahun Chanie
Jimma University, Ethiopia
ScientificTracks Abstracts: J Clin Trials
DOI: 10.4172/2167-0870-C1-013
Background: The life expectancy of people living with human immunodeficiency virus (HIV) has dramatically improved with the much increased access to antiretroviral therapy. Consequently, a larger number of people living with HIV are living longer and facing the increased burden of non-communicable diseases. Objective: To assess effect of chronic diseases comorbidities and determinants of treatment outcomes among HIV infected patients on highly active anti-retroviral therapy at Jimma University Specialized Hospital. Methods: A nested case-control study was conducted among people living with HIV at Jimma University Specialized Hospital from February 20 to August 20, 2016. Patient specific data was collected using structured data collection tool to identify relevant information and also patient reported outcome quality of life-HIV (PROQOL-HIV) scale was used to assess health related quality of life of patient. Data was analyzed using statistical package for Social Science version 20.0. Logistic and linear regressions were done to identify factor associated to outcomes. Statistical significance was considered at p-value <0.05. Results: A total of 160 participants, 80 cases and 80 controls were included in the analysis. Among cases; hypertension accounts 13.8%, followed by diabetes (11.9%) and about 12.5% had multimorbidity. At baseline, the mean (±SD) age of cases was 42.32±10.69 years, whereas it was 38.41±8.23 years among controls. The median baseline CD4+ cell count was 184.50 cells/μL (IQR: 98.50-284.00 cells/μL) for cases and 177.0 cells/μL (IQR: 103.75-257.25 cells/μL) for controls. Post 6-months of highly active anti-retroviral therapy initiation, immunologic failure was 28.80% among cases and it was 16.25% among controls. An average increase of CD4+ cell count was 6.4 cells per μL per month among cases and 7.6 cells per μL per month among controls. The mean±SD score of health related quality of life among cases was 57.39±6.89, 73.52±13.22, 64.15±9.03, 81.37±8.31 and it was 71.74±21.64, 76.48±11.88, 67.25±9.67, 81.53±8.08 among controls in physical health and symptoms, health concerns and mental distress, social and intimate relationships, treatment-related impact dimension respectively. Male sex [AOR, 3.51; 95% CI, 1.496 to 8.24; p=0.004], smoking history [AOR, 2.81; 95% CI, 1.072, to 7.342; p=0.036] and comorbidity with noncommunicable chronic diseases [AOR 3.99; 95% CI, 1.604 to 9.916; p=0.003)] are independent predictors of immunologic failure. Conclusions & Recommendations: Chronic non-communicable diseases have negative effects on the kinetics of CD4+ cell count and also have negative impact on quality of life among HIV-infected patients who initiated antiretroviral therapy. So integration of chronic non-communicable disease-HIV collaborative activities will strengthen battle to control double burden of chronic illnesses.

Tsegaye Melaku Kebede is a Lecturer and Clinical Pharmacist at School of Pharmacy, Institute of Health Sciences, Jimma University, Ethiopia. His interests span across enhancing his capacity through continuing education and solving health care problems of his community.


image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version