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Mortality rate is 10-20 times higher among patients with end stage renal disease, compared with general population,
with 50% of this excess burden being attributable to cardiovascular disease. This excess risk is not entirely explained by elevation
of traditional risk factors. Elevation of Several Non-traditional risk factors is associated with an increased risk for cardiovascular
disease in CKD (not on dialysis) and haemodialysis dependent patients. .
48 pre-dialysis CKD, 22 Heamodialysis dependent patients and 26 healthy controls were included in the study. Non-
traditional risk factors homocysteine, fibrinogen, C-reactive protein (CRP), factor VII activity and haemoglobin were estimated
and compared with normal control population..
Homocysteine was 15.38 ? 5.06, 27.30 ? 31.12, 23.76 ? 9.15 μmol/L in control , pre-dialysis CKD and haemodialysis
dependent patient respectively. Fibrinogen in control , pre-dialysis CKD and haemodialysis dependent patient was 180.25 ?
40.64, 264.10 ? 67.81, 259.59 ? 60.92mg/dl respectively. CRP in control, pre-dialysis CKD and haemodialysis dependent patient
was 3.90? 1.03 52.59 ? 82.16, 17.31 ? 18.42 mg/L respectively. Factor VII activity in control was 94.18 ? 12.66, in pre-dialysis
CKD 103.97 ? 14.41 and haemodialysis dependent patient 106.18 ? 14.64. Haemoglobin was in control 13.85 ? 1.59gm/dl, pre-
dialysis CKD 8.08 ? 1.94 gm/dl, Haemodialysis dependent patients 9.46 ? 1.87gm/dl. Cardiovascular disease in pre-dialysis CKD
was 54.56% and haemodialysis dependent patients 59.4%. Compared to control both in pre-dialysis CKD and haemodialysis
dependent patients homocysteine , fibrinogen , CRP, factor VII were significantly increased and haemoglobin was significantly
Non traditional risk factors may be responsible for increased incidence of cardiovascular disease in pre-dialysis
CKD and haemodialysis dependent patients
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