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Non-traditional Cardiovascular Risk Factors In Chronic Kidney Disease (CKD) And Haemodialysis Dependent Patients- A Case Control Study | 4339
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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Non-traditional cardiovascular risk factors in chronic kidney disease (CKD) and haemodialysis dependent patients- A case control study

International Conference and Exhibition on Nephrology & Therapeutics

Md. Muhibur Rahman and Ratan Das Gupta

ScientificTracks Abstracts: J Nephrol Therapeut

DOI: 10.4172/2161-0959.S1.004

Abstract
Background: Mortality rate is 10-20 times higher among patients with end stage renal disease, compared with general population, with 50% of this excess burden being attributable to cardiovascular disease. This excess risk is not entirely explained by elevation of traditional risk factors. Elevation of Several Non-traditional risk factors is associated with an increased risk for cardiovascular disease in CKD (not on dialysis) and haemodialysis dependent patients. . Methods: 48 pre-dialysis CKD, 22 Heamodialysis dependent patients and 26 healthy controls were included in the study. Non- traditional risk factors homocysteine, fibrinogen, C-reactive protein (CRP), factor VII activity and haemoglobin were estimated and compared with normal control population.. Results: Homocysteine was 15.38 ? 5.06, 27.30 ? 31.12, 23.76 ? 9.15 μmol/L in control , pre-dialysis CKD and haemodialysis dependent patient respectively. Fibrinogen in control , pre-dialysis CKD and haemodialysis dependent patient was 180.25 ? 40.64, 264.10 ? 67.81, 259.59 ? 60.92mg/dl respectively. CRP in control, pre-dialysis CKD and haemodialysis dependent patient was 3.90? 1.03 52.59 ? 82.16, 17.31 ? 18.42 mg/L respectively. Factor VII activity in control was 94.18 ? 12.66, in pre-dialysis CKD 103.97 ? 14.41 and haemodialysis dependent patient 106.18 ? 14.64. Haemoglobin was in control 13.85 ? 1.59gm/dl, pre- dialysis CKD 8.08 ? 1.94 gm/dl, Haemodialysis dependent patients 9.46 ? 1.87gm/dl. Cardiovascular disease in pre-dialysis CKD was 54.56% and haemodialysis dependent patients 59.4%. Compared to control both in pre-dialysis CKD and haemodialysis dependent patients homocysteine , fibrinogen , CRP, factor VII were significantly increased and haemoglobin was significantly low . Conclusions: Non traditional risk factors may be responsible for increased incidence of cardiovascular disease in pre-dialysis CKD and haemodialysis dependent patients
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