alexa Non-V600 BRAF Mutations Define A Distinct Molecular Subtype Of Metastatic Colorectal Cancer
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

16th Global Annual Oncologists Meeting
April 24-25, 2017 Dubai, UAE

Humaid O Alshamsi
Mayo Clinic, USA
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-096
Background: Molecular diagnostic testing has become an integral part of the evaluation of patients with metastatic colorectal cancer (CRC). However, expanded mutational testing often identifies mutations with unclear clinical, therapeutic or prognostic implications. One such example is BRAF mutations which occur outside of codon 600 (non-V600BRAF mutations). Methods: We completed this multicenter, retrospective cohort study to fully characterize the clinical, pathologic and survival implications of non-V600BRAF mutations in metastatic CRC. We identified and pooled all patients with CRC in whom non- V600BRAF mutations were identified from NGS databases at three large molecular genetics reference labs. Findings: A total of 9643 patients with metastatic CRC underwent NGS testing. We identified 208 patients with non-V600BRAF mutations, which accounted for 21.5% of all BRAF mutations. The estimated prevalence of non-V600BRAF mutations in all patients tested was 2.2%. Cancers with non-V600BRAF compared with V600EBRAF mutations were found in patients who were significantly younger (58 vs. 68 years; p<0.0001), less likely to be female (46% vs. 65%; p=0.0008), and had less high grade (13% vs. 64%; p<0.0001), or right-sided primary tumors (36% vs. 81%; p<0.0001). Median overall survival (OS) was significantly longer in patients with non-V600BRAF mutations compared to those with V600EBRAF-mutant metastatic CRC (OS: 60.7 months vs. 11.4 months; p<0.0001). In multivariate analysis, non-V600BRAF mutation remained independently associated with improved OS (HR: 0.18; p< 0.0001). Interpretation: Non-V600BRAF mutations occur in approximately 2.2% of patients with metastatic CRC and define a new subtype of CRC with an excellent prognosis.

Humaid Al-Shamsi is currently working as an Assistant Professor, University of Texas MD Anderson Cancer Center and he is also positioned as an Assistant Clinical Professor (Part Time) in the Department of Oncology at McMaster University. He has been a recipient of many awards and grants. His research experience includes various programs, contributions and participation at different countries for diverse fields of study. His research interests reflect in his wide range of publications in various national and international journals. His research interests include Oncology, Radialogy, Hepatology, Clinical Oncology, etc.


image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version