Novel Controlled Release Microsponges For Topical Infections | 19066
Pharmaceutical Regulatory Affairs: Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The present study deals with the formulation and evaluation of microsponge drug delivery system of neomycin sulphate
by using the polymer ethyl cellulose. Neomycin sulphate has shorter half-life (2 hrs) and severe systemic side effects
like nephrotoxicity and neurotoxicity. The percutaneous absorption increases risk associated with systemic absorption of
topically applied formulation. Controlled release of drug to the skin could reduce the side effects while reducing percutaneous
absorption. Therefore, the aim of the present study was to produce Neomycin sulphate entrapped microporous microparticles
(microsponges) to control the release of drug to the skin. Microsponges were prepared by previously optimized quasi-emulsion
solvent diffusion method. Compatibility of drug with reaction adjuncts was studied by FT-IR and DSC. The production yield,
loading efficiency, particle size analysis and surface morphology of microsponges were performed. Microparticles were then
incorporated into carbopol 934 gels and further the drug release and skin deposition studies were conducted. Free flowing
powder microsponges were spherical in shape, between 13.8 and 78.3 μm in diameter. FT-IR and DSC studies revealed
absence of primary incompatibility between formulation adjuvants and process parameters. Surface morphology by scanning
electron microscopy revealed micro-porous nature of microsponges. Drug release was observed controlled with comparative
anti-bacterial activity with the gels containing free drug. Animal studies showed improvement in reducing infections when
compared to market preparation.
Gannu Praveen Kumar has completed his MPharmacy from Birla Institute of Technology and Science, Pilani and PhD from Kakatiya University. He is the Principal
of Sahasra Institute of Pharmaceutical Sciences, Warangal. He has published more than 30 papers in reputed journals and is also serving as an advisor and
consultant of repute pharmaceutical companies and participated in many social activities.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals