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Novel Co-processed Excipients Of Mannitol And Microcrystalline Cellulose For Preparing Fast Dissolving Tablets Of Fexofenadine Hydrochloride | 7574
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Novel co-processed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets of fexofenadine hydrochloride

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Shobhit Sharma, M.P. Khinchi, Dilip Agrawal, Natasha Sharma, M.P. Kabra and M.K. Gupta

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Abstract
Co-processed particles of mannitol and microcrystalline cellulose were fabricated by spray drying technique to be used as a direct compression excipient in fast dissolving tablet formulation. Microcrystalline cellulose passed through sieve no.80, having a volumetric mean diameter (d50) of 30.85 μm, was used to form composite particles with powdered mannitol which was previously passed through sieve no. 80, in various mixing ratios. The composite particles were evaluated for their powder and compression properties. An increase in the microcrystalline cellulose proportion imparted greater compressibility to the composite particles, but the flowability of these mixtures was decreased. Although microcrystalline cellulose and mannitol have been extensively used in the formulation of fast dissolving tablets, the non-wetting property of the hard compact central core may delay the disintegration time. Optimized co-processed formulation containing mannitol and microcrystalline cellulose in the ratio of 1.5:1 was found to have optimized powder and compressibility characteristics with fast disintegrating property (<15 s). The fast disintegration may be due to the partial amorphization and formation of submicron particles of mannitol. These results indicated that improved fast dissolving tablets could be prepared by the co-processed mixture of microcrystalline cellulose and mannitol. Finally fast dissolving tablets of Fexofenadine were prepared by blending with other excipients and compressed into tablets. Sensory study on disintegration time and mouth feel attributes ranked the present formulation based on grittiness, chalkiness and overall preference as the best.
Biography
Shobhit Sharma completed B. Pharma in 2007 from Rajiv Academy for Pharmacy, Mathura (U.P.). Presently he is M. Pharma Pharmaceutics Student in Kota College of Pharmacy, Kota (Rajasthan). Shobhit is having 4 International review articles, 2 International research articles and He is attended 2 National conferences in Delhi and in Solan (H.P.). His Research Guide is Dr. M.P. Khinchi is having 15 International Research Articles, 20 International Review Articles and he is Attended 12 National Conferences
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