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Type 2 diabetes is associated with a physiological condition termed as insulin resistance, which is characterized by inability
of insulin to stimulate glucose uptake in insulin sensitive tissues, such as the skeletal muscles and adipose tissue. Skeletal
muscles are the major site for glucose utilization and plays important role in maintaining glucose homeostasis. In skeletal muscles
insulin resistance is caused by impaired translocation and distribution of insulin sensitive transporter-4 (GLUT-4) to cell surface
which affects the entry of glucose inside the cells. Hence stimulation of glucose uptake in skeletal muscle cells provides an
approach to cure the type2 diabetes and other related metabolic disorders viz obesity, hypertension, glucose intolerance and
cardiovascular diseases. In today?s scenario natural products and their derivatives with glucose uptake stimulatory effect may
provide a novel approach for the management of insulin resistance associated with type 2 diabetes and metabolic disordersin a
safe, effective and cost effective manner. In the present study analogues of imbricatolic acid isolated from the choloform fraction
of Cupressussempervirens were evaluated for their anti-diabetic potential under invitro conditions. The analogues of imbricatolic
acid were synthesized by insertion of N-substituted piperazine moieties and evaluated for their glucose uptake stimulatory effects
on L6 skeletal muscle cells. Out of tested compounds, 4b, 4e, 8b and 8e triggered glucose uptake to a significant level at 10 μM
concentration. Compound 4b was found to be most active and has emerged as important lead compounds showing potential
anti-diabetic activity. Therefore4b may have the potential for treatment of insulin resistance and associated metabolic disorders.
I am Jyotsna Pandey, a fresher in the field of research. Presently working as Project Assistant Level ? II at Central Drug Research Institute, Lucknow
on type 2 diabetes. I have completed M.Sc. in Biotechnology from Amity University Uttar Pradesh in 2011. I have 2 research publication one in
Bioorganic Medicinal Chemistry Letters (Impact factor 4.5) and Other in Trends in Carbohydrate Research journals.
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