alexa Novel Insights Into The Molecular Mechanisms Of Interferon Resistance Of Hepatitis C And B Viruses Based On Gene Expression Profiling
ISSN: 2161-0517

Virology & Mycology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

10th World Congress on Virology and Mycology
May 11-12, 2017 Singapore

Limin Chen
University of Toronto, Canada
Keynote: Virol-mycol
DOI: 10.4172/2161-0517-C1-019
Abstract
Hepatitis viruses, including Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infect human liver leading to chronic infections that gradually develop into cirrhosis and hepatocellular carcinoma (HCC). Current treatment regimen includes interferon and nucleotide analogues (NAs). Although direct acting anti-viral agents (DAAs) clear the virus in more than 95% individuals chronically infected with HCV, pegylated interferon is still widely used in many Asian countries. Unfortunately, not all patients chronically infected with HCV respond to pegylated interferon/ribavirin combination therapy. As such, understanding the molecular mechanisms of interferon resistance of HCV and HBV is essential for better management of patients. Based on gene expression profiling, we identified an 18-gene response signature that can be used to predict whether a given patients will respond to interferon-based therapy with an accuracy of 96%. A novel ubiquitin-like ISG15/USP18 signaling pathway was also identified to be involved in interferon resistance in both HCV and HBV infections. A series of functional studies on ISG15 and USP18 genes revealed the detailed molecular mechanisms of interferon resistance of HBV and HCV. Data from our studies indicated that ISG15 (and ISG15 conjugation-the process called ISGylation) stimulated HCV replication and potentiated the interferon anti-HCV activity. Silencing of USP18 boosts the antiviral activity of interferon against hepatitis C virus infection through activation of the Jak/STAT signaling in vitro HCV culture (HCVcc) model.
Biography

Limin Chen is serving as a Professor with the Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) and also an Affiliated Scientist with the University of Toronto. Currently, he is the Director and Chief Scientific Officer of the Center for Transfusion Transmitted Diseases, Institute of Blood Transfusion (IBT), CAMS/PUMC, member of the American Association for Studies of Liver Diseases (AASLD) and Canadian Association for Studies of Liver (CASL). He obtained his MD and MSc in Biochemistry and Molecular Biology in China and PhD in Molecular Genetics at the University of Toronto. He obtained his Post-doctoral training both at the Merck Research Laboratories and at the Harvard Medical School. Currently, his research focuses on the virus-host interaction of the hepatitis viruses, especially HCV. He pioneered the work on identification of the response signature and proposed a novel mechanism on how HCV exploits host innate immune response to benefit its persistent infection and resistance to interferon-based therapy.

Emal: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords