alexa
Reach Us +443308085114
Novel Pharmacologic And Phenotypic Methods To Characterize Carrier-mediated And Nanoparticle Agents As Part Of Preclinical And Clinical Development | 10424
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Novel pharmacologic and phenotypic methods to characterize carrier-mediated and nanoparticle agents as part of preclinical and clinical development

2nd International Conference and Exhibition on Biowaivers & Biosimilars

William C. Zamboni

ScientificTracks Abstracts: J Bioanal Biomed

DOI: 10.4172/1948-593X.S1.010

Abstract
Nanoparticle drugs consist of the inactive-drug that remains encapsulated within or conjugated to the nanoparticle carrier and the active-drug that is released from the carrier. The pharmacokinetics and pharmacodynamics of nanoparticle agents is dependent on their recognition and interaction with the mononuclear phagocyte system (MPS) where the encapsulated drug is cleared via the MPS and the drug may be released from the carrier via interactions with the MPS. Thus, it is critically important to evaluate the encapsulated and released forms of nanoparticle agents and how nanoparticle agents interact with the MPS in preclinical models and in patients. The following issues will be discussed: 1) pharmacologic methods to characterize nanoparticle agents in vivo and in vitro ; 2) animal models for pharmacologic and toxicology studies of nanoparticle agents; and the development of phenotypic probes of the MPS to profile nanoparticle agents, animal models and as a method to individualize nanoparticle therapy in patients.
Biography
William Zamboni received his bachelor of science, doctor of pharmacy and doctor of philosophy from the University of Pittsburgh, School of Pharmacy in Pittsburgh, Pennsylvania. He completed his oncology residency at the Warren G. Magnuson Clinical Center, National Institutes of Health, in Bethesda, MD and his research fellowship at the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, in Memphis, Tennessee. Currently, he is an Associate Professor in the UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center. Zamboni?s research program is part of the Division of Pharmacotherapy and Experimental Therapeutics n the UNC Eshelman School of Pharmacy and Molecular Therapeutics in the UNC Lineberger Comprehensive Cancer Center. He is the director of UNC GLP Bioanalytical Facility and the director of the Translational Oncology and Nanoparticle Drug Development Initiative (TOND 2 I) Lab at the University of North Carolina in Chapel Hill. He is also the Codirector of the North Carolina Biomedical Innovation Network (NCBIN) for GLP toxicology and pharmacology studies of small molecule and nanoparticle agents.
Top