alexa Novel Protective Effects Of Baicalin On High-glucose Induced Chick Embryo Malformation And Its Molecular Mechanisms
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
July 24-25, 2017 Melbourne, Australia

Jian-Xin Liang, Lin-Rui Gao, Li-Guo Chen, Guang Wang and Xue-Song Yang
Key Laboratory for Regenerative Medicine, China
Institute of Integrated Traditional Chinese and Western, China
Jinan University, China
Posters & Accepted Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836-C1-017
Abstract
Baicalin, which is a traditional Chinese monomer isolated from a traditional Chinese tocolytic medicine; Baical skullcap root, has shown the ability of anti-oxygenation. Here, we investigated for the first time whether baicalin treatment could improve the high-glucose induced chick embryo malformation and uncovered its underlying mechanisms. In our study, we have found certain concentration of baicalin did not affect the development of early chick embryo. The number of high-glucose induced heart tube and blood island malformation in chick embryos were decreased in baicalin treating. Western blot analysis of the experimental chick embryos revealed that GATA-4 was inhibited, while LC3-II and C-caspase-3 were increased following high glucose treatment. However, baicalin treatment could improve the expression of these genes. In addition, we confirmed that the baicalin could improve the cell survival through both anti-oxygenation and regulating autophagy in vitro. Therefore, our data indicated that baicalin could be a potential candidate for gestational diabetes induced malformation.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version