The Renin-Angiotensin-Aldosterone System (RAAS) is a regulator of blood pressure as well as kidney functions and is
suggested to play an important role in the development of nephropathy in Type 2 Diabetes. Aldosterone is an important
component of RAAS, and plays an important role in controlling blood pressure, water and electrolyte homeostasis in the body.
Aldosterone synthase gene (CYP11B2) polymorphism has been reported to be associated with serum aldosterone level, blood
pressure, and diabetic complication such as nephropathy and left ventricular size and mass. The aim of this study was to evaluate
the relation between CYP11B2 gene (-344 C>T) promoter polymorphism and type 2 diabetic patients in the Indian population.
The present study was carried out among 323 subjects of both sexes, consisting of 205 type 2 diabetes patients (T2DM) and 118
healthy controls. Genotyping was performed by polymerase chain reaction -restriction fragment length polymorphism analysis
(PCR-RFLP). The frequencies of CYP11B2 gene CC, CT, TT genotypes among the cases T2DM, and Controls are (13.17 %, 51.70
%, and 35.12 %. T2DM; 16.95 %, 38.14 %, 44.91 % controls) respectively. Our study failed to identify any association of CYP11B2
gene (-344 C>T) promoter polymorphism with type 2 diabetic patients in Indian population.
Pulakes Purkait is a doctoral student under Dept. of Anthropology, Andhra University. He is also as Senior Research Fellow under Anthropological Survey of India, WRC, Udaipur. He has a number of publications in Nationaland International reputed journals.
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