alexa Nutritional And Genotoxic Stress Contributes To Diabetes And Neurodegenerative Diseases Such As Parkinson?s And Alzheimer?s Diseases
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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5th World Congress on Diabetes & Metabolism
November 03-05, 2014 Embassy Suites Las Vegas, USA

Ian Martins
ScientificTracks Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.S1.026
Abstract
The global epidemic indicates that one third of adults in the United States are obese and over 11% of these individuals have diabetes with the incidence of diabetes predicated to increase to 21% by 2050. In various continents, the rise in the global diabetes epidemic has been associated with cell suicide in various organs that are related to obesity; Type 2 diabetes and neurodegenerative diseases. Therapeutics to control and stabilize the severity of the metabolic syndrome and diabetes in various communities are required to prevent mental illness and early cellular senescence that is connected to the lifespan of diabetics. The increased cell senescence in diabetes has been associated with the limited ability of cells to divide with indication of telomere shortening and genomic instability is connected to cell suicide. Diet and liver diseases are closely connected and are of central importance with aging and programmed cell death pathways. Nutritional therapy and appetite control have become of central importance to nutrigenomics as early nutritional therapy may assist genes to delay liver and brain diseases associated with insulin resistance, cancer and aging. Interests in the global epidemic in Type 2 diabetes have been associated with accelerated dementia and even with progression to Parkinson?s disease (PD) and Alzheimer?s disease (AD). Anti-aging therapies such as diet, exercise and selective drug therapy early in life may prevent calorie overload and activation of calorie sensitive genes Sirtuin 1 (Sirt 1) that control genotoxic stress in cardiovascular disease and diabetes that accelerates aging, PD and AD.
Biography
Ian Martins is a Fellow at the Centre for Ageing and Alzheimer?s disease, Edith Cowan University and UWA. His contribution to biology is related to sterol side chain length indicating cholesterol as a metabolic control of liver lipoprotein and xenobiotic metabolism. His publications, patents, books and chapters have been filed for evaluation of education for obesity, diabetes and AD. He is the Chief Editor for Scientific and Academic Publishing (2013/2014) and a reviewer for international journals and Grant agencies.
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