Reach Us +1-504-608-2390
Observations On Coronary Artery Adventitial Inflammation In Patients Who Died Of Acute Coronary Disease (ACD) | 7876
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Observations on coronary artery adventitial inflammation in patients who died of acute coronary disease (ACD)

2nd International Conference on Clinical Research Cardiology, Ophthalmology & Dermatology

Richard Frink

ScientificTracks Abstracts: J Clinic Experiment Cardiol

DOI: 10.4172/2155-9880.S1.04

Background: Atherosclerosis is a chronic inflammatory disease, but the significance of adventitial inflammation is not completely understood. Methods: The coronary arteries of 83 patients who died of acute coronary disease and 22 control patients were injected with a colored barium gelatin mass and the heart fixed in formalin. After fixation, the coronary arteries were dissected intact, decalcified, cut a 2-3 mm intervals and all segments mounted for microscopic study.7,056 segments were examined, including 3-5 sub- serial sections from each segment.The frequency of adventitial inflammation, and the number of segments with >50% luminal stenosis was determined to estimate the overall plaque burden (PB).All plaque disruptions (PD?S), including erosions, fissures and plaque ruptures, with and without associated luminal thrombosis, were noted. Results: Adventitial inflammatory infiltrates were present in over 50% of 7,056 segments, were always located over plaques and never over normal wall, showing adventitial inflammation is a diffuse process.The extent of adventitial inflammation increased with plaque enlargement, suggesting a direct relationship exists between PB and adventitial inflammation.211 PD?s were found in these 83 patients, with 27 (13%) in segments with <50% luminal stenosis.Luminal thrombosis was relatively infrequent and associated with a PD in approximately 50% of cases. Conclusions: Adventitial inflammation appears to be a reliable histologic marker of active, progressive, atherosclerotic disease, and may be helpful in identifying the insignificant appearing vulnerable plaque that has the potential to progress rapidly and cause acute events. Many PD?s are not associated with luminal thrombosis.
Dr. Frink is the Principal Investigator of the Heart Research Foundation of Sacramento. He received his training at Iowa, Mayo Clinic and Alabama. He practiced invasive cardiology in Sacramento for 35 years and at the same time established a histology photographic laboratory to study the post-mortem heart. He performed extensive post-mortem examinations of the hearts of over 150 of patients who died of acute coronary disease, as well as hearts of pigs and sheep. He has published approximately 25 research papers and a book detailing the pathologic findings in patients who died of acute coronary disease.