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The delivery of poorly water-soluble drugs has been the subject of much research, also some drugs are unstable in the
presence of water therefore cannot be incorporated into aqueous formulation. To overcome these problems emulsions can be
formulated without an aqueous phase to produce non-aqueous or oil-in-oil emulsions. As there are no guidelines for the selection
of surfactants to stabilize two immiscible non-polar oils we are continuing to study a wider range of nonaqueous systems to
develop a better understanding of stabilization. Perhaps an analogue of HLB, a lipophile (1)-lipophile (2) balance (L1L2B) may
be used to predict surfactant choice. Well-stabilized systems will find uses in controlled release & mechanism of absorption of
drugs from oily solutions involves two different absorption routes. Firstly, drug molecules were taken up together with the direct
absorption of small oil droplets, and secondly, drug was absorbed after being transferred from the oily depot into the aqueous
phase which surrounded the injection site. Further studies on formulation, drug release from intramuscular & subcutaneous
depots of these non-aqueous systems are about to begin.
Miss Yashoda V. Mane, doing M. Pharm. (Pharmaceutics) at Shivaji University, Kolhapur. She has presented various posters in national conferences.
She is Life Member of Indian Pharmaceutical Association.
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