Olive Oil Oleuropein Has Anti-breast Cancer Properties With Higher Efficiency On ER-negative Cells | 33707
Journal of Cancer Science & Therapy
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Breast cancer constitutes a major health problem for women worldwide. However, its incidence varies between populations
and geographical locations. These variations could be diet-related, since there are several carcinogenic compounds in the
modern diet, while natural products contain various anti-cancer elements. Several lines of evidence indicate that, in addition to
their clear preventive effect, these compounds could also be used as therapeutic agents. In the present report we have shown that
oleuropein, a pharmacologically safe natural product of olive leaf, has potent anti-breast cancer properties. Indeed, oleuropein
exhibits specific cytotoxicity against breast cancer cells, with higher effect on the basal-like MDA-MB-231 cells than on the
luminal MCF-7 cells. This effect is mediated through the induction of apoptosis via the mitochondrial pathway. Moreover,
oleuropein inhibits cell proliferation by delaying the cell cycle at S phase and up-regulated the cyclin-dependent inhibitor
p21. Furthermore, oleuropein inhibited the anti-apoptosis and pro-proliferation protein NF-κB and its main oncogenic target
cyclin D1. This inhibition could explain the great effect of oleuropein on cell proliferation and cell death of breast cancer cells.
Therefore, oleuropein warrants further investigations to prove its utility in preventing/treating breast cancer, especially the
less-responsive basal-like type.
Maha H Elamin received B.Sc from Cairo University, Egypt. M.Sc and Ph.D, from Gezira University, Sudan. The Ph.D was in Medical and molecular parasitology. I have joined the department of Molecular Oncology at King Faisal Specialist Hospital and Research Center, Riyadh, KSA as a researcher in breast cancer for 7 years. Currently, Iam working as an Associate professor in Zoology department, King Saud University, Riyadh, KSA.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals