alexa One Pot Synthesis Of Dihydropyrano[3,2-c]chromenes And Their Evaluation Of Antimicrobial And In Vitro Anticancer Activity
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
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3rd International Conference on Mass Spectrometry
October 10-11, 2016 Kuala Lumpur, Malaysia

Amit S Waghmare and Dayanand M Suryawanshi
Padmashri Vikhe Patil College, India
Annasaheb Awate College, India
Posters & Accepted Abstracts: J Chromatogr Sep Tech
DOI: 10.4172/2157-7064.C1.023
Abstract
The three-component of one-pot synthesis of dihydropyrano[3,2-c]chromene derivatives are obtained in good to excellent yields within short reaction time by condensing 4-hydroxycoumarin, aldehydes and malononitrile or ethyl cyanoacetate with a catalytic amount of (diacetoxyiodo)benzene (DIB) as hypervalent iodine in aqueous ethanol under reflux condition has been reported. Some of the newly synthesized compounds were screened against two Gram negative, two Gram positive bacteria and two fungi using broth micro dilution MIC method. Compounds 4n, 4q, and 4o showed good activity and compounds 4g, 4k and 4n showed moderate activity against bacteria. Selected compounds were tasted for anticancer activity. Compound 4k and 4n showed activity against human astrocytoma-glioblastoma cell line (U373MG).
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