alexa Oral Albendazole Is Effective Against Phthiriasis Palpebrarum
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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14th International Conference on Clinical and Experimental Dermatology
June 19-20, 2017 Philadelphia, USA

Marc Mrad and Ribal Merhi
Pierre-and-Marie-Curie University, France
Centre Hospitalier Universitaire Notre Dame des Secours, Lebanon
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554-C1-060
Abstract
Introduction: Treatment of Phthiriasis palpebrarum is based on the mechanical ablation of lice and nits after topical vaseline application, shaving of the eyelashes, oral ivermectin administration, application of pilocarpine gel, fluorescein drops, yellow mercury oxide ointment, permethrin cream, lindane lotion or malathion shampoo. The emergence of resistant strains, the risk of major eye damage and the favorable benzimidazole outcomes in pediculosis capitis and pubic phthaliasis, prompted us to use albendazole against ciliary phthiriasis. We report a case of ciliary phthiriasis resistant to several therapeutic modalities having responded to albendazole per os. Observations: A seven year child with no significant personal or family history was seen in our outpatient clinic for ocular pruritus. The diagnosis of ciliary phthiriasis was made on the physical examination, which identified the presence of small brownish crusts at the base of the eyelashes, associated with visible lice and nits. The patient was previously treated with several local applications of permethrin 1% cream and a daily occlusive treatment with vaseline for 2 weeks, with no significant result. Due to the absence of ivermectin, a dose of 400 mg of albendazole per os was administered to the patient (J0), and repeated after seven days (J8). Complete resolution of the clinical signs and symptoms was noted. No recurrence was observed after a six month follow-up. Since the presence of ciliary phthiriasis may indicate possible sexual abuse, the hospital's social service was informed for investigations. Discussion: Albendazole inhibits polymerization of tubulin into microtubules and has a high affinity for parasitic tubulin, sparing those of the mammalian hosts. Loss of cytoplasmic microtubules alters glucose absorption by larvae and helminths, causing a decrease in ATP and energy depletion, resulting in the immobilization and death of the parasite. The principle of oral albendazole is based on the intake of a blood meal containing the insecticide. For this reason the nits are not affected and the treatment must be repeated after 7 days. Given its price, safety, rare and limited side effects, albendazole could be considered as a therapeutic option in ciliary phthiriasis.
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