Orderly perforation of polymer films by excimer laser for possible use as scaffold materials in tissue engineering

International Conference and Exhibition on Biopolymers & Bioplastics

August 10-12, 2015 San Francisco, USA

Erol Sancaktar1, Efkan ��at�±ker2, Kimberly Sloan Stakleff3 and Kelly Carr3

Posters-Accepted Abstracts: J Material Sci Eng

Abstract :

This study involved the effects of excimer laser perforation of biodegradable (PHB and PLA) and non-biodegradable (PU/
PDMS and PMMA) polymer films on cell proliferation on and around them in cell culture cells. The ultimate goal is to use such
membranes as scaffold materials in tissue engineering. The cell-matrices interactions were examined based on the proliferation of
human fibroblast cells cultured on the laser-perforated membranes, and as well as on the as-cast films and tissue culture plastic for
comparisons. Our cell culture tests using the perforated PLA and PMMA membranes revealed significant improvements in cell
proliferation when compared with the corresponding cases of as-cast films. We can conclude, therefore, that laser-induced perforation
of biodegradable PLA and non-biodegradable PMMA polymer films with perforation sizes of up to 43 μm can render them effective
scaffold materials for tissue engineering.