Overlap Of Proteomics Biomarkers Between Women With Pre-eclampsia And PCOS: A Systematic Review And Biomarker Database Integration | 16456
Journal of Molecular Biomarkers & Diagnosis
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Various studies have indicated an association between Polycystic Ovary Syndrome (PCOS) and pre-eclampsia
(PE), however the pathophysiological mechanisms supporting this association are unclear. Defining such mechanisms linking
PCOS and PE, could assist in more accurate screening, and underpin novel preventative strategies for pre eclampsia.
The aim of this study was to catalogue proteomic biomarkers in PE and considers whether any represent candidate
biomarkers for the detection of PET risk in women with PCOS.
A systematic review and update of our PCOS proteomic biomarker database was performed, along with a parallel
review of PE biomarkers. All eligible published studies on proteomic biomarkers for PE and PCOS which were identified
through MEDLINE (1996-December 2013), EMBASE (1980-December 2013) and Cochrane (1993-December 2013) ISI web
of knowledge (v4.2) databases, using the search terms ?proteomics?, ?proteomic?, ?pre-eclampsia?, ?pre-eclamptic toxemia,
?proteomic biomarker?, ?proteomic biomarker? and ?polycystic ovary syndrome? without any restrictions were evaluated. The
primary studies on PE were used to create a first database of proteomic biomarkers for PE, whereas those on PCOS to update
our existing PCOS database. The two databases were then compared and searched for overlaps; proteomic biomarkers that
were common to women with PCOS and PE.
Five proteomic biomarkers were differentially expressed in both in women with PE and PCOS compared to controls:
transferin, fibrinogen alpha, beta and gamma chain variants, kininogen-1, annexin 2 and peroxiredoxin 2. In PE the biomarkers
were found in serum, plasma and placenta and in PCOS the biomarkers were identified in serum, follicular fluid, ovarian and
These proteomic biomarkers could potentially be used to understand the pathophysiological mechanisms
linking PCOS and PE. The biomarkers may help to identify subgroups of women with PCOS at risk of developing PE and early
diagnosis of PE could be helpful in the management of the women at risk.
Gulafshana Hafeez Khan did her medical degree from University of Peshawar, Pakistan and then did post graduation in Obstetrics and Gynaecology from
College of Physicians and Surgeons Pakistan. She has trained in Obstetrics and Gynaecology in the UK and is a Member of Royal College of Obstetricians and
Gynaecologists since 2004. She is currently doing PhD in Obstetrics and Gynaecology in School of Medicine, University Of Nottingham. Her special interest is
reproductive medicine and general Obstetrics
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