alexa Ovulation Induction Options For Women With Polycystic Ovarian Syndrome
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd World Congress on Polycystic Ovarian Syndrome
October 05-07, 2016 Orlando, Florida, USA

Gregory M Christman
University of Florida, USA
Keynote: Endocrinol Metab Syndr
DOI: 10.4172/2161-1017.C1.013
Abstract
Background: Clomiphene has long been the traditional first-line treatment for women with polycystic ovary syndrome, with letrozole used infrequently in clinical practice as an alternative option. Methods: In a double-blind, multicenter trial, 750 women with PCOS, in a 1:1 ratio, received letrozole or clomiphene for up to 5 treatment cycles, with visits to determine ovulation and pregnancy. Participants were 18 - 40 years of age, had at least one patent fallopian tube and had a male partner with at least 14 million sperm per milliliter. Women and their partners agreed to have regular intercourse with the intent of conception during the study. The primary study outcome was live birth. Results: Women who received letrozole had more cumulative live births than those who received clomiphene (103 of 374 [27.5%] vs. 72 of 376 [19.1%], P=0.007; rate ratio for live birth, 1.44; 95% confidence interval, 1.10 to 1.87) without significant differences in congenital anomalies. The cumulative ovulation rate was higher with letrozole than with clomiphene (834 of 1352 treatment cycles [61.7%] vs. 688 of 1425 treatment cycles [48.3%], P<0.001). There were no significance between-group differences in pregnancy loss or twin pregnancy. Clomiphene was associated with a higher incidence of hot flushes, and letrozole with a higher incidence of fatigue. Conclusions: As compared with clomiphene, letrozole was associated with higher live-birth among infertile women with polycystic ovary syndrome.
Biography

Gregory M Christman has recently joined the University of Florida to direct the Division of Reproductive Endocrinology and Infertility. He completed his medical school and residency training at the University of Wisconsin before pursuing NIH Post-doctoral Research Training in Endocrinology at the University of Michigan. He completed a Clinical Fellowship in Reproductive Endocrinology at the University of North Carolina before joining the faculty at the University of Michigan (1992-2013). He was the Principal Investigator involved in the last cycle of the NICHD Reproductive Medicine Trial Network and the Pregnancy in Polycystic Ovarian Disease II Trial.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

medicaljournal[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords