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Oxidative Damage And Pharmacokinetics Of The Benzonitrile Herbicide, Pendimethalin In Rat | 52231

Journal of Neuroscience and Neuropharmacology
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Oxidative damage and pharmacokinetics of the Benzonitrile herbicide, Pendimethalin in rat

4th Global Experts Meeting on Neuropharmacology

Ahmed K Salama, Khaled A Osman, Ahmed S El-Bakary and Maher S Salama

Majmaah University, KSA Alexandria University, Egypt

ScientificTracks Abstracts: Neurochem Neuropharm

DOI: 10.4172/2469-9780.C1.002

The oxidative damage and pharmacokinetics of pendimethalin were studied in male rat. Rats were divided into four groups. To conduct the pharmacokinetic study, the 1st group received a single oral dose of 109 mg pendimethalin /kg body weight and the 2nd group received a single oral dose of corn oil and served as control. To conduct the oxidative damage study, the 3rd group received four oral doses of 109.4 mg/kg b.wt every other day and the 4th group received corn oil as the same manner and served as control. Rats of 1st and 2nd groups were killed after 0.5, 1, 3, 6, 12, 24, 48, 72, 120, and 168 h. Pendimethalin was readily absorbed and subsequently distributed throughout the body. The peak concentrations of the herbicide reached in serum, liver and kidney at 12 h and in brain at 24 h following administration. The compound began to decline in all tissues as time passed. Pendimethalin disappeared biexponentially from serum, liver, kidneys and brain. The terminal half-life t½ of pendimethalin was 14.0, 15.0, 2.5, and 29.0 h for the serum, liver, brain and kidneys, respectively. At termination of 168 h, the urinary and fecal cumulative excretion rose to 23.81 and 71.21%, respectively. Rats of 3rd and 4th groups were killed 24 h after the last dose. Exposure of rats to pendimethalin caused a significant increase in tissue MDA, LDH and ALP levels as compared to controls. The activities of catalase (CAT) in serum, liver and kidney were significantly increased, while brain CAT activity was significantly decreased due to pendimethalin treatment. Our results indicated that there was no tendency for pendimethalin to retain in rat tissue. The results also showed that pendimethalin exposure had profound influence on the oxidative stress markers and enzyme activities of the exposed male rat and these enzymes can be used as biomarkers in determining pendimethalin toxicity.

Ahmed K Salama is a Professor of Applied Chemistry and Toxicology at Majmaah University, KSA and Alexandria University, Egypt. He has been the Head of Medical Laboratories department from 2007 to 2014. He was the Deputy Director of the Medical Laboratories Program at Majmaah University from 2010 to 2014. He obtained his PhD from Duke University Medical Center, North Carolina, USA through a channel system with Alexandria University, Egypt. His overall research interest is directed toward pesticides risk assessment; oxidative stress and tissue damage induced by pesticides; pharmacokinetics and metabolism of pesticides. He has many peer reviewed publications and edited books.

Email: [email protected]