alexa PARP1 Dependent Long-term Memory Acquisition

Journal of Neuroscience and Neuropharmacology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 

7th Global Experts Meeting on NEUROPHARMACOLOGY
July 31-August 02, 2017 | Milan, Italy

M Cohen-Armon
Tel Aviv University, Israel
Keynote: Neurochem Neuropharm
DOI: 10.4172/2469-9780-C1-004
Abstract
Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, is also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk2 synergism, which may underlie this phenomenon. A stimulation induced PARP1 binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk-induced PARP1 activation, rendering transcription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound phosphorylated Erk2. PARP1 inhibition, silencing, or genetic deletion abrogated stimulation-induced Erk-recruitment to IEG promoters, IEG expression and LTP generation in hippocampal CA3-CA1-connections. Moreover, a predominant binding of PARP1 to single-strand DNA breaks, occluding its Erk binding sites, suppressed IEG expression prevented the generation of LTP. These findings suggested that Erk-induced PARP1 activation mediates IEG expression implicated in synaptic plasticity and in long-term memory acquisition which deteriorates in senescence when aged cerebral neurons accumulate DNA single-strand breaks. These findings may be also implicated in a PARP1 dependent mechanism associated with reward-related memory retrieval.
Biography

M Cohen-Armon received BSc in Chemistry (cum laude) and DSc in Biophysics & Electrophysiology from the Technion, Israel. From 1992 – present, she is holding Academic position in Faculty of Medicine, Dept. of Physiology and Pharmacology at the Tel-Aviv University of Life Sciences. In 2001, she was a Visiting Researcher in the Lab of Learning and Memory, Columbia University, New York, in collaboration with Late Prof. James Schwartz. She is an Academic Editor in PLOS ONE and Am. J. of Alzheimer's Disease & Other Dementias. In 2004, she along with Prof. Schwartz first reported on a mechanism in the chromatin that is required for long-term memory acquisition during learning. Their finding was reported in Science, and was accompanied by Press Release in USA and Israel. She has carried out research in various other fields including human solid cancer cells and at present, her applied research on PJ34 is supported by Novartis.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords